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Monoclonal Mouse Anti-Human
CD5
Clone 4C7
Reacts with CD5 expressed on B and T cells and may be useful for the identification of B and T-cell malignancies.
This includes B-cell chronic lymphoid leukemia (B-CLL), B-cell small lymphocytic lymphoma (B-SLL), mantle cell lymphoma (MCL) and T-cell lymphoma and leukemia (1-4).
References
- Diaz de Leon E, Alkan S, Huang JC, Hsi ED. Usefulness of an immunohistochemical panel in paraffin-embedded tissues for the differentiation of B-cell non-Hodgkin's lymphomas of small lymphocytes. Mod Pathol 1998;11:1046-51.
- Dorfman DM, Shahsafaei A. Usefulness of a new CD5 antibody for the diagnosis of T-cell and B-cell lymphoproliferative disorders in paraffin sections. Mod Pathol 1997;10:859-63.
- Arber DA, Weiss LM. CD5 a review. Appl Immunohistochem 1995;3:1-22.
- Watson P, Wood KM, Lodge A, McIntosh GG, Milton I, Piggott NH, et al. Monoclonal antibodies recognizing CD5, CD10 and CD23 in formalin-fixed, paraffin-embedded tissue: production assessment of their value in the diagnosis of small B-cell lymphoma. Histopathol 2000;36:145-50.
Mantle cell lymphoma (FFPE) stained with FLEX Anti-CD5, Code IR082/IS082.
Mantle cell lymphoma. The neoplastic cells show a moderate to strong membraneous staining reaction
Clinical application for IR082/IS082. For identification of B- and T-cell malignancies, including B-cell chronic lymphocytic leukemia/ small lymphocytic lymphoma, mantle cell lymphoma, and T-cell lymphoma and leukemia.
Disclaimer: Due to variances among color computer monitors, the colors you see on your screen may not be the exact colors of the stain. The image you see should be considered close renditions to the actual stain.
- Optimized staining performance of both high- and low-expression structures
- Crisp and clear staining with no background
- Optimal laboratory efficiency with ready-to-use antibodies on Dako Autostainer Link 48
Intended Use
For in vitro diagnostic use.
FLEX Monoclonal Mouse Anti-Human CD5, Clone 4C7, Ready-to-Use (Link), is intended for use in immunohistochemistry together with Autostainer Link instruments. The antibody labels CD5-positive cells and may be useful for the identification of B- and T-cell malignancies including B-cell chronic lymphoid leukemia (B CLL), B-cell small lymphocytic lymphoma (B-SLL), mantle cell lymphoma (MCL) and T-cell lymphoma and leukemia (1-4). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
FLEX Monoclonal Mouse Anti-Human CD5, Clone 4C7, Ready-to-Use (Link), is intended for use in immunohistochemistry together with Autostainer Link instruments. The antibody labels CD5-positive cells and may be useful for the identification of B- and T-cell malignancies including B-cell chronic lymphoid leukemia (B CLL), B-cell small lymphocytic lymphoma (B-SLL), mantle cell lymphoma (MCL) and T-cell lymphoma and leukemia (1-4). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
Immunogen
Recombinant prokaryotic fusion protein corresponding to the external domain of the human CD5 molecule.
Specificity
Human CD5 molecule, 67 kDa.
Reagent Provided
Ready-to-use monoclonal rabbit antibody provided in liquid form in a buffer containing stabilizing protein and 0.015 mol/L sodium azide.
Clone: 4C7 (4). Isotype: IgG1, kappa.
Clone: 4C7 (4). Isotype: IgG1, kappa.
References
- Diaz de Leon E, Alkan S, Huang JC, Hsi ED. Usefulness of an immunohistochemical panel in paraffin-embedded tissues for the differentiation of B-cell non-Hodgkin's lymphomas of small lymphocytes. Mod Pathol 1998;11:1046-51.
- Dorfman DM, Shahsafaei A. Usefulness of a new CD5 antibody for the diagnosis of T-cell and B-cell lymphoproliferative disorders in paraffin sections. Mod Pathol 1997;10:859-63.
- Arber DA, Weiss LM. CD5 a review. Appl Immunohistochem 1995;3:1-22.
- Watson P, Wood KM, Lodge A, McIntosh GG, Milton I, Piggott NH, et al. Monoclonal antibodies recognizing CD5, CD10 and CD23 in formalin-fixed, paraffin-embedded tissue: production and assessment of their value in the diagnosis of small B-cell lymphoma. Histopath 2000;36:145-50.
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| Product | Size |  | IR082 Clone 4C7
| 60 tests, 12 mL Product No. IR08261-2 |
|---|
RECOMMENDED COMPANION PRODUCTS
| Step | Product | Size |
|---|---|---|
| Pre-treatment | EnVision™ FLEX Target Retrieval Solution, High pH (Code K8004) 3-in-1 procedure using PT Link | 3 x 30 mL Product No. K800421-2 |
| Antibody Dilution | Ready-to-use / Prediluted | |
| Negative Control | FLEX Negative Control, Mouse (Code IR750) Positive tissue: Tonsil | 120 tests, 24 mL Product No. IR75066-2 |
| Visualization System | EnVision™ FLEX (Code K8000) Use High pH Target Retrieval Solution | 400-600 tests Product No. K800021-2 |
| Counterstain | Hematoxylin (Link) (Code K8008) Non-aqueous, permanent mounting medium is required | 3 x 45 mL, 400-600 tests Product No. K800821-2 |
| Glass Slides | Silanized Slides (Code S3003) Recommended for greater adherence Alternative is FLEX IHC Microscope Slides (Code K8020) | 100 slides Product No. S300330-2 |
Synonym(s) for Antigen
T1, Tp67