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Monoclonal Mouse Anti-Human
CD23
Clone DAK-CD23
CD23 is primarily expressed on B cells and monocytes, including a strong expression on Epstein-Barr Virus-transformed B lymphoblasts.
Together with a panel of antibodies, anti-CD23 is particularly useful for differentiation between CD23-positive B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma and CD23-negative mantle cell lymphoma (1).
- Rossi S, Laurino L, Furlanetto A, Chinellato S, Orvieto E, Canal F, et al. Rabbit monoclonal antibodies: a comparative study between a novel category of immunoreagents and the corresponding mouse monoclonal antibodies. Am J Clin Pathol 2005;124:295-302.
B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma (FFPE) stained with FLEX Anti-CD23, Clone DAK-CD23, Code IR781/IS781.
B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma. The majority of the neoplastic cells show a distinct membranous staining reaction.
Clinical application for IR781/IS781. For identification of both normal B cells and malignant lymphomas such as B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma. Mantle cell lymphoma is generally negative for CD23.
Disclaimer: Due to variances among color computer monitors, the colors you see on your screen may not be the exact colors of the stain. The image you see should be considered close renditions to the actual stain.
- Optimized staining performance of both high- and low-expression structures
- Crisp and clear staining with no background
- Optimal laboratory efficiency with ready-to-use antibodies on Dako Autostainer Plus
FLEX Monoclonal Mouse Anti-Human CD23, Clone DAK-CD23, Ready-to-Use (Dako Autostainer/Autostainer Plus), is intended for use in immunohistochemistry together with Dako Autostainer/Autostainer Plus instruments. Antibodies to CD23 are useful for the identification of both normal B lymphocytes and malignant lymphomas. Together with a panel of antibodies, anti-CD23 is particularly useful for differentiation between B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma and mantle cell lymphoma (1). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
Clone: DAK-CD23. Isotype: IgG1, kappa.
- Rossi S, Laurino L, Furlanetto A, Chinellato S, Orvieto E, Canal F, et al. Rabbit monoclonal antibodies: a comparative study between a novel category of immunoreagents and the corresponding mouse monoclonal antibodies. Am J Clin Pathol 2005;124:295-302.
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| Product | Size |  | IS781 Clone DAK-CD23
| 30 tests, 6 mL Product No. IS78130 |
|---|
RECOMMENDED COMPANION PRODUCTS
| Step | Product | Size |
|---|---|---|
| Pre-treatment | EnVision™ FLEX Target Retrieval Solution, High pH (Code K8004) 3-in-1 procedure using PT Link | 3 x 30 mL Product No. K800421-2 |
| Antibody Dilution | Ready-to-use / Prediluted | |
| Negative Control | FLEX Negative Control, Mouse (Code IS750) Positive tissue: Tonsil | 60 tests, 12 mL Product No. IS75061-2 |
| Visualization System | EnVision™ FLEX+ (Code K8012) Use High pH Target Retrieval Solution | 400-600 tests Product No. K801221-2 |
| Counterstain | Hematoxylin (Dako Autostainer/Autostainer Plus) (Code K8018) Non-aqueous, permanent mounting medium is required | 10 x 13 mL, 400-600 tests Product No. K801821-2 |
| Glass Slides | FLEX IHC Microscope Slides (Code K8020) Recommended for greater adherence | 5 x 100 slides Product No. K802021-2 |
Synonym(s) for Antigen
FcεRII, BLAST-2, low affinity IgE receptor