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Monoclonal Mouse Anti-Human
CDX2
Clone DAK-CDX2
Cdx2, a human gene homologous to the Drosophila caudal-type homeobox gene, encodes a transcription factor, which is involved in proliferation and differentiation of intestinal epithelial cells.
The CDX2 protein is widely expressed in intestinal epithelium from the duodenum to the rectum. Scattered expression has been reported in pancreatic ductules, while no expression has been observed in other normal tissues tested. The majority of colorectal adenocarcinomas, a large part of gastric adenocarcinomas, carcinoids of the GI tract as well as adenocarcinomas of the ovary, urinary bladder and pancreas show CDX2 expression. Antibodies to CDX2 may be useful for identification of both primary and metastatic tumors of the gastrointestinal tract, including carcinoids.
Isotype IgG1, kappa
- Frozen
- Formalin
- HIER
Colon adenocarcinoma (FFPE) stained with FLEX Anti-CDX2, Code IR080/IS080.
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Colon adenocarcinoma. The neoplastic cells show a strong nuclear staining reaction.
Clinical application for IR080/IS080. For identification of adenocarcinoma and carcinoids of the gastrointestinal tract.
Carcinoids. The tumor cells of a gastrointestinal carcinoid tumor show a strong nuclear staining reaction.
Clinical application for IR080/IS080. For identification of adenocarcinoma and carcinoids of the gastrointestinal tract.
Appendix. Mucosal epithelial cells show a strong nuclear staining reaction.
Recommended control for IR080/IS080. Appendix/Pancreas.
Pancreas. The intercalated epithelial cells show a weak to moderate nuclear staining reaction.
Recommended control for IR080/IS080. Appendix/Pancreas.
Colon adenocarcinoma stained with Anti-CDX2.
Clinical application for IR080/IS080. For identification of adenocarcinoma and carcinoids of the gastrointestinal tract.
Disclaimer: Due to variances among color computer monitors, the colors you see on your screen may not be the exact colors of the stain. The image you see should be considered close renditions to the actual stain.
- Concentrated Antibody
for Manual Use - Ready-to-use Antibody
for Autostainer Link Instrument - Ready-to-use Antibody
for Autostainer Plus Instrument
- Excellent specificity
- High lot to lot consistency
- Optimized for immunohistochemistry (IHC) with validated protocols
- Certified manufacturing facilities guarantee full quality control
Intended Use
For in vitro diagnostic use.
Monoclonal Mouse Anti-Human CDX2, Clone DAK-CDX2, is intended for use in immunohistochemistry. Antibodies to CDX2 may be useful for the identification of cells from adenocarcinomas and carcinoids of the gastrointestinal tract. The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
Monoclonal Mouse Anti-Human CDX2, Clone DAK-CDX2, is intended for use in immunohistochemistry. Antibodies to CDX2 may be useful for the identification of cells from adenocarcinomas and carcinoids of the gastrointestinal tract. The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
Immunogen
Monoclonal mouse antibody provided in liquid form as cell culture supernatant (containing fetal bovine serum) dialyzed against 0.05 mol/L Tris/HCl, pH 7.2, and containing 0.015 mol/L sodium azide.
Clone: DAK-CDX2. Isotype: IgG1, kappa.
Mouse IgG concentration mg/L: See label on vial.
The protein concentration between lots may vary without influencing the optimal dilution. The titer of each individual lot is compared and adjusted to a reference lot to ensure a consistent immunohistochemical staining performance from lot-to-lot.
Clone: DAK-CDX2. Isotype: IgG1, kappa.
Mouse IgG concentration mg/L: See label on vial.
The protein concentration between lots may vary without influencing the optimal dilution. The titer of each individual lot is compared and adjusted to a reference lot to ensure a consistent immunohistochemical staining performance from lot-to-lot.
Specificity
In Western blotting of Caco-2 lysate the antibody labels a 37 kDa and 40 kDa band corresponding to the expected molecular weight of CDX2 (2, 11). Additional bands at 17 kDa and 19 kDa were also labeled by the antibody (11).
Reagent Provided
Monoclonal mouse antibody provided in liquid form as cell culture supernatant (containing fetal bovine serum) dialyzed against 0.05 mol/L Tris/HCl, pH 7.2, and containing 0.015 mol/L sodium azide.
Clone: DAK-CDX2. Isotype: IgG1, kappa.
Mouse IgG concentration mg/L: See label on vial.
The protein concentration between lots may vary without influencing the optimal dilution. The titer of each individual lot is compared and adjusted to a reference lot to ensure a consistent immunohistochemical staining performance from lot-to-lot.
Clone: DAK-CDX2. Isotype: IgG1, kappa.
Mouse IgG concentration mg/L: See label on vial.
The protein concentration between lots may vary without influencing the optimal dilution. The titer of each individual lot is compared and adjusted to a reference lot to ensure a consistent immunohistochemical staining performance from lot-to-lot.
References
- Suh E, Chen L, Taylor J, Traber PG.A homeodomain protein related to caudal regulates intestine-specific gene transcription. Mol Cell Biol 1994;14:7340-51.
- M3636 WB042908-152 Report on File.
| Product | Size |  | M3636 Culture supernatant
| 0.2 mL Product No. M363629 |
|---|---|---|
| 1 mL Product No. M363601 |
- Optimized staining performance of both high- and low-expression structures
- Crisp and clear staining with no background
- Optimal laboratory efficiency with ready-to-use antibodies on Dako Autostainer Link 48
Intended Use
For in vitro diagnostic use.
FLEX Monoclonal Mouse Anti-Human CDX2, Clone DAK-CDX2, Ready-to-Use (Link), is intended for use in immunohistochemistry together with Autostainer Link instruments. Antibodies to CDX2 may be useful for the identification of cells from adenocarcinomas and carcinoids of the gastrointestinal tract. The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
FLEX Monoclonal Mouse Anti-Human CDX2, Clone DAK-CDX2, Ready-to-Use (Link), is intended for use in immunohistochemistry together with Autostainer Link instruments. Antibodies to CDX2 may be useful for the identification of cells from adenocarcinomas and carcinoids of the gastrointestinal tract. The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
Immunogen
Recombinant human CDX2 corresponding to amino acids 1-165.
Specificity
In Western blotting of Caco-2 lysate the antibody labels a 37 kDa and 40 kDa band corresponding to the expected molecular weight of CDX2 (2). Additional bands at 17 kDa and 19 kDa were also labeled by the antibody.
Reagent Provided
Ready-to-use monoclonal mouse antibody provided in liquid form in a buffer containing stabilizing protein and 0.015 mol/L sodium azide.
Clone: DAK-CDX2. Isotype: IgG1, kappa.
Clone: DAK-CDX2. Isotype: IgG1, kappa.
References
- Suh E, Chen L, Taylor J, Traber PG. A homeodomain protein related to caudal regulates intestine-specific gene transcription. Mol Cell Biol 1994;14:7340-51.
| Product | Size | | IR080 RTU, FLEX
| 60 tests, 12 mL Product No. IR08061 |
|---|
RECOMMENDED COMPANION PRODUCTS
| Step | Product | Size |
|---|---|---|
| Pre-treatment | EnVision™ FLEX Target Retrieval Solution, High pH (Code K8004) 3-in-1 procedure using PT Link | 3 x 30 mL Product No. K800421 |
| Antibody Dilution | Ready-to-use / Prediluted | |
| Negative Control | FLEX Negative Control, Mouse (Code IR750) Positive tissue: Appendix and pancreas | 120 tests, 24 mL Product No. IR75066 |
| Visualization System | EnVision™ FLEX (Code K8000) Use High pH Target Retrieval Solution | 400-600 tests Product No. K800021 |
| Counterstain | Hematoxylin (Link) (Code K8008) Non-aqueous, permanent mounting medium is required | 3 x 45 mL, 400-600 tests Product No. K800821 |
| Glass Slides | Silanized Slides (Code S3003) Recommended for greater adherence Alternative is FLEX IHC Microscope Slides (Code K8020) | 100 slides Product No. S300330 |
- Optimized staining performance of both high- and low-expression structures
- Crisp and clear staining with no background
- Optimal laboratory efficiency with ready-to-use antibodies on Dako Autostainer Plus
Intended Use
For in vitro diagnostic use.
FLEX Monoclonal Mouse Anti-Human CDX2, Clone DAK-CDX2, Ready-to-Use (Dako Autostainer/Autostainer Plus), is intended for use in immunohistochemistry together with Dako Autostainer/Autostainer Plus instruments. Antibodies to CDX2 may be useful for the identification of cells from adenocarcinomas and carcinoids of the gastrointestinal tract. The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
FLEX Monoclonal Mouse Anti-Human CDX2, Clone DAK-CDX2, Ready-to-Use (Dako Autostainer/Autostainer Plus), is intended for use in immunohistochemistry together with Dako Autostainer/Autostainer Plus instruments. Antibodies to CDX2 may be useful for the identification of cells from adenocarcinomas and carcinoids of the gastrointestinal tract. The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
Immunogen
Recombinant human CDX2 corresponding to amino acids 1-165.
Specificity
In Western blotting of Caco-2 lysate the antibody labels a 37 kDa and 40 kDa band corresponding to the expected molecular weight of CDX2 (2). Additional bands at 17 kDa and 19 kDa were also labeled by the antibody.
Reagent Provided
Ready-to-use monoclonal mouse antibody provided in liquid form in a buffer containing stabilizing protein and 0.015 mol/L sodium azide.
Clone: DAK-CDX2. Isotype: IgG1, kappa.
Clone: DAK-CDX2. Isotype: IgG1, kappa.
References
- Suh E, Chen L, Taylor J, Traber PG. A homeodomain protein related to caudal regulates intestine-specific gene transcription. Mol Cell Biol 1994;14:7340-51.
| Product | Size | | IS080 RTU, FLEX
| 30 tests, 6 mL Product No. IS08030 |
|---|
RECOMMENDED COMPANION PRODUCTS
| Step | Product | Size |
|---|---|---|
| Pre-treatment | EnVision™ FLEX Target Retrieval Solution, High pH (Code K8004) 3-in-1 procedure using PT Link | 3 x 30 mL Product No. K800421 |
| Antibody Dilution | Ready-to-use / Prediluted | |
| Negative Control | FLEX Negative Control, Mouse (Code IS750) Positive tissue: Appendix and pancreas | 60 tests, 12 mL Product No. IS75061 |
| Visualization System | EnVision™ FLEX (Code K8010) Use High pH Target Retrieval Solution | 400-600 tests Product No. K801021 |
| Counterstain | Hematoxylin (Dako Autostainer/Autostainer Plus) (Code K8018) Non-aqueous, permanent mounting medium is required | 10 x 13 mL, 400-600 tests Product No. K801821 |
| Glass Slides | Silanized Slides (Code S3003) Recommended for greater adherence Alternative is FLEX IHC Microscope Slides (Code K8020) | 100 slides Product No. S300330 |
Synonym(s) for Antigen
Caudal-type homeobox protein 2