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HER2 CISH pharmDx™ Kit
HER2 CISH pharmDx™ Kit is a dual color chromogenic assay designed to quantitatively determine HER2 gene amplifications in formalin-fixed, paraffin-embedded breast cancer tissue specimens using bright field microscopy. Gene amplification is determined from the ratio between the number of signals from the visualization of the HER2 gene probe (red signals) and the number of signals from the reference chromosome 17 probe (blue signals).
HER2 CISH pharmDx™ Kit is indicated as an aid in the assessment of patients for whom Herceptin™ treatment is being considered. Results are intended for use as an adjunct to the information currently used for estimating prognosis in stage II, node-positive breast cancer patients.
Chromogenic Dual Color visualization
Interpretation by Bright Field Microscopy
Preservation of Morphology
HER2 CISH pharmDx™ Kit is indicated as an aid in the assessment of patients for whom Herceptin™ treatment is being considered. Results are intended for use as an adjunct to the information currently used for estimating prognosis in stage II, node-positive breast cancer patients.
Chromogenic Dual Color visualization
- Allows fast and convenient method for scoring
- Improves scoring ratios accuracy due to counting both HER2 gene signals and centromere signals in the same cells on one slide
- Distinguishes true gene amplifications or deletions from chromosomal aneuploidy
Interpretation by Bright Field Microscopy
- Saves the expense and the required use of a fluorescence microscope
- Stained sections can be stored at room temperature without loss of signals
- Provides the opportunity to archive and re-evaluate at any time
Preservation of Morphology
- Enables easy and fast identification of invasive tissue and internal control