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Polyclonal Rabbit Anti-Human
Myeloperoxidase
The antigen has been isolated from primary granulocytes (1). The antibody reacts with neutrophil granulocytes and monocytes in blood and with precursors of granulocytes in the bone marrow.
The antibody is valuable for discrimination between lymphoid and myeloid leukemias and as an aid in the classification of neoplastic tissue, i.e. myeloblasts and immature myeloid cells of acute myelogenous leukemia, progranulocytic leukemia, monomyelocytic leukemia, erythroleukemia and myeloblastoma (2) .
- Matheson NR, Wong PS, Travis J. Isolation and properties of human neutrophil myeloperoxidase. Biochem 1981;20:325-30.
- Pinkus GS, Pinkus JI. Myeloperoxidase: a specific marker for myeloid cells in paraffin sections. Mod Pathol 1991;4:733-41.
Acute myeloid leukemia (FFPE) stained with FLEX Anti-Myeloperoxidase, Code IR511/IS511.
Acute myeloid leukemia (M4). A strong granular cytoplasmic staining reaction is seen in part of the neoplastic cells, and a weak or absent staining is observed in the monocytes.
Clinical application for IR511/IS511 For differential diagnosis between lymphoid and myeloid tumors as myeloid tumors are generally positive and lymphoid tumors negative.
Disclaimer: Due to variances among color computer monitors, the colors you see on your screen may not be the exact colors of the stain. The image you see should be considered close renditions to the actual stain.
- Optimized staining performance of both high- and low-expression structures
- Crisp and clear staining with no background
- Optimal laboratory efficiency with ready-to-use antibodies on Dako Autostainer Link 48
FLEX Polyclonal Rabbit Anti-Human Myeloperoxidase, Ready-to-Use (Link), is intended for use in immunohistochemistry together with Autostainer Link instruments. The antibody labels myeloperoxidase-positive cells in normal and neoplastic tissues and is a useful tool for the discrimination between lymphoid and myeloid disorders. Positive results aid in the classification of neoplastic tissue (i.e. myeloblasts and immature myeloid cells of acute myelogenous leukemia, progranulocytic leukemia, monomyelocytic leukemia, erythroleukemia and myeloblastoma) (1). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
In formalin-fixed, paraffin-embedded human tonsil, and when using a sensitive streptavidin-biotin-based visualization system, the antibody as expected labels only rare neutrophil granulocytes.
- Pinkus GS, Pinkus JI. Myeloperoxidase: A specific marker for myeloid cells in paraffin sections. Mod Pathol 1991; 4:733
| Product | Size |  | IR511
| 60 tests, 12 mL Product No. IR51161 |
|---|
RECOMMENDED COMPANION PRODUCTS
| Step | Product | Size |
|---|---|---|
| Pre-treatment | EnVision™ FLEX Target Retrieval Solution, High pH (Code K8004) 3-in-1 procedure using PT Link | 3 x 30 mL Product No. K800421 |
| Antibody Dilution | Ready-to-use / Prediluted | |
| Negative Control | FLEX Negative Control, Rabbit (Code IR600) Positive tissue: Tonsil and liver | 120 tests, 24 mL Product No. IR60066 |
| Visualization System | EnVision™ FLEX (Code K8000) Use High pH Target Retrieval Solution | 400-600 tests Product No. K800021 |
| Counterstain | Hematoxylin (Link) (Code K8008) Non-aqueous, permanent mounting medium is required | 3 x 45 mL, 400-600 tests Product No. K800821 |
| Glass Slides | FLEX IHC Microscope Slides (Code K8020) Recommended for greater adherence | 5 x 100 slides Product No. K802021 |