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Polyclonal Rabbit Anti-Human
Chromogranin A
The antigen used for immunization is the C-terminal half (Mr 23000) of chromogranin A isolated from urine of patients with carcinoid tumors.
A reference to the use of anti-chromogranin in the study of tumors of neuroendocrine origin is (1).
- Kimura N, Sasano N, Yamada R, Satoh J. Immunohistochemical study of chromogranin in 100 cases of pheochromocytoma, carotid body tumour, medullary thyroid carcinoma, and carcinoid tumour. Virch Arch [A] 1988;413:33-8.
Small cell lung carcinoma (FFPE) stained with FLEX Anti-Chromogranin A, Code IR502/IS502.
Small cell lung carcinoma. The majority of the neoplastic cells show a finely granular, distinct cytoplasmic and focally dot-like staining reaction.
Clinical application for IR502/IS502. For identification of neuroendocrine cells and tumors with neuroendocrine differentiation.
Disclaimer: Due to variances among color computer monitors, the colors you see on your screen may not be the exact colors of the stain. The image you see should be considered close renditions to the actual stain.
- Optimized staining performance of both high- and low-expression structures
- Crisp and clear staining with no background
- Optimal laboratory efficiency with ready-to-use antibodies on Dako Autostainer Link 48
FLEX Polyclonal Rabbit Anti-Human Chromogranin A, Ready-to-Use (Link), is intended for use in immunohistochemistry together with Autostainer Link instruments. This antibody labels chromogranin A present in secretory granules of endocrine cells (1). Chromogranin A is a marker for neuroendocrine differentiation and antibodies to chromogranin A are useful for identification of neuroendocrine-derived tumors. The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
As demonstrated by immunohistochemistry on formalin-fixed, paraffin-embedded tissue sections, the antibody cross-reacts with the chromogranin A-equivalent protein in cow, horse and swine.
- Moorghen M, Carpenter F. Peanut lectin: a histochemical marker for phaeochromocytomas. Virchows Arch A Pathol Anal Histopathol 1991; 419:203-7.
| Product | Size |  | IR502
| 60 tests, 12 mL Product No. IR50261 |
|---|
RECOMMENDED COMPANION PRODUCTS
| Step | Product | Size |
|---|---|---|
| Pre-treatment | EnVision™ FLEX Target Retrieval Solution, High pH (Code K8004) 3-in-1 procedure using PT Link | 3 x 30 mL Product No. K800421 |
| Antibody Dilution | Ready-to-use / Prediluted | |
| Negative Control | FLEX Negative Control, Rabbit (Code IR600) Positive tissue: Colon | 120 tests, 24 mL Product No. IR60066 |
| Visualization System | EnVision™ FLEX (Code K8000) Use High pH Target Retrieval Solution | 400-600 tests Product No. K800021 |
| Counterstain | Hematoxylin (Link) (Code K8008) Non-aqueous, permanent mounting medium is required | 3 x 45 mL, 400-600 tests Product No. K800821 |
| Glass Slides | FLEX IHC Microscope Slides (Code K8020) Recommended for greater adherence | 5 x 100 slides Product No. K802021 |