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Monoclonal Mouse Anti-Human
Actin (Muscle)
Clone HHF35
Labels myocardial, skeletal and smooth muscle cells as well as myoepithelial cells.
The antibody recognizes rhabdomyosarcomas, leiomyomas and leiomyosarcomas, and also reacts with 'myofibroblasts' in the stroma of certain tumors including many carcinomas.
Rhabdomyosarcoma (FFPE) stained with FLEX Anti-Actin (Muscle), Code IR700/IS700.
Rhabdomyosarcoma. The majority of the neoplastic cells show a weak to moderate staining reaction.
Clinical application for IR700/IS700. For identification of soft tissue tumors with muscle differentiation, i.e. leiomyoma, leiomyosarcoma and rhabdomyosarcoma.
Disclaimer: Due to variances among color computer monitors, the colors you see on your screen may not be the exact colors of the stain. The image you see should be considered close renditions to the actual stain.
- Optimized staining performance of both high- and low-expression structures
- Crisp and clear staining with no background
- Optimal laboratory efficiency with ready-to-use antibodies on Dako Autostainer Link 48
FLEX Monoclonal Mouse Anti-Human Muscle Actin, Clone HHF35, Ready-to-Use (Link), is intended for use in immunohistochemistry together with Autostainer Link instruments. This antibody is useful for the identification of soft tissue tumors with muscle differentiation, i.e. leiomyoma (LM), leiomyosarcoma (LMS) (1), and rhabdomyosarcoma (RMS) (1, 2). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
Clone: HHF35 (1, 4). Isotype: IgG1, kappa.
- Tsukada T, McNutt MA, Ross R, Gown A. HHF35, A muscle-actin-specific monoclonal antibody. II. Reactivity in normal, reactive, and neoplastic human tissues. Amer J Pathol 1987;127:389-402.
- Schmidt R, Cone R, Haas J, Gown A. Diagnosis of rhabdomyosarcomas with HHF35, a monoclonal antibody directed against muscleactins. Amer J Pathol 1988;131:19-28.
- Tsukada T, Tippens D, Gordon D, Ross R, Gown A. HHF35, a muscle-actin specific monoclonal antibody. I. Immunocytochemical and biochemical characterization. Amer J Pathol 1987;126:51-60.
| Product | Size |  | IR700 Clone HHF35
| 60 tests, 12 mL Product No. IR70061 |
|---|
RECOMMENDED COMPANION PRODUCTS
| Step | Product | Size |
|---|---|---|
| Pre-treatment | EnVision™ FLEX Target Retrieval Solution, High pH (Code K8004) 3-in-1 procedure using PT Link | 3 x 30 mL Product No. K800421 |
| Antibody Dilution | Ready-to-use / Prediluted | |
| Negative Control | FLEX Negative Control, Mouse (Code IR750) Positive tissue: Colon and tongue | 120 tests, 24 mL Product No. IR75066 |
| Visualization System | EnVision™ FLEX (Code K8000) Use High pH Target Retrieval Solution | 400-600 tests Product No. K800021 |
| Counterstain | Hematoxylin (Link) (Code K8008) Non-aqueous, permanent mounting medium is required | 3 x 45 mL, 400-600 tests Product No. K800821 |
| Glass Slides | FLEX IHC Microscope Slides (Code K8020) Recommended for greater adherence | 5 x 100 slides Product No. K802021 |