Monoclonal Mouse Anti-Human

Progesterone Receptor

Clone PgR 636

Progesterone receptor (PR) is a steroid hormone receptor that plays an important role in breast cancer. The absence of PR and estrogen receptor (ER) predicts early recurrence and poor survival of breast cancer patients.

The antibody to PR is useful for measuring the relative level of expression of progesterone receptor in breast cancer tissue. This antibody is indicated for use as an aid in the management, prognosis and prediction of outcome of breast cancer.

Breast ductal carcinoma (FFPE) stained with FLEX Anti-Progesterone Receptor.

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Breast ductal carcinoma. The neoplastic cells show a strong nuclear staining reaction

Clinical application. For measuring of the relative level of expression for progesterone receptor in breast cancer tissue. It also labels meningioma cells.

Disclaimer: Due to variances among color computer monitors, the colors you see on your screen may not be the exact colors of the stain. The image you see should be considered close renditions to the actual stain.

  • Optimized staining performance of both high- and low-expression structures
  • Crisp and clear staining with no background
  • Optimal laboratory efficiency with ready-to-use antibodies on Dako Autostainer Plus
The staining performance of all antibodies has been defined, tested and approved through collaboration with leading international pathologists. Check the Atlas of Stains - a guide to diagnostic accuracy

Intended Use
For in vitro diagnostic use.

FLEX Monoclonal Mouse Anti-Human Progesterone Receptor, Clone PgR 636, Ready-to-Use (Dako Autostainer/Autostainer Plus), is intended for use in immunohistochemistry together with Dako Autostainer/Autostainer Plus instruments. This antibody is useful for measuring the relative level of expression for progesterone receptor in breast cancer tissue. This antibody is indicated for use as an aid in the management, prognosis and prediction of outcome of breast cancer. The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
Immunogen
Formalin-fixed recombinant full-length A-form of human progesterone receptor (1).
Specificity
Anti-PR, PgR 636 has been demonstrated to react with the PR-A and PR-B forms by Western blot of whole cell extracts and reacts with both free and hormone-bound PR (1). The epitope has been mapped to the amino terminal domain shared by PR-A and PR-B.
Reagent Provided
Ready-to-use monoclonal mouse antibody provided in liquid form in a buffer containing stabilizing protein and 0.015 mol/L NaN3.

Clone: PgR 636 (1). Isotype: IgG1, kappa.
References
  1. Press M, Spaulding B, Groshen S, Kaminsky D, Hagerty M, Sherman L, Christensen K, Edwards DP. Comparison of different antibodies for detection of progesterone receptor in breast cancer.
    Steroids 2002;67:799-813.
ProductSize
This product is CE-marked according to the EU IVD Directive 98/79/ECIS068 Clone PgR 636
Specification Sheet
Safety Data Sheet:
Non-hazard classification statement
30 tests, 6 mL
Product No. IS06830

Synonym(s) for Antigen

PR, PgR636

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