Dako's range of probes aims at the most predominant molecular markers in cancer diagnostics and research. Dako has successfully introduced the peptide nucleic acid (PNA) probe, a nucleotide analog capable of binding to DNA/RNA in a sequence-specific mannuer. This increases the affinity of our probes thereby enhancing the visualization. Furthermore, the PNAs are very stable. In clinical experiments to degradation by DNAases, Rnases, proteinases or peptidases has been observed, ensuringf that you receive optimal test results.
In situ hybridization (ISH) techniques are used to localize specific nucleic acid sequences within the cells of tissues or cytological preparations, on chromosomes, or in whole mounts. Development of non-radioactive probes and detection systems has made this technology available to a wide variety of routine applications.