Brazil
Product is distributed by:
Biogen Ltda.
Rua Paulistania
319-Sumarezinho
05440-000 São Paulo
+55 11 3819 3191
+55 11 3819 3191
www.biogenbr.com.br
biogen@biogenbr.com.br
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Monoclonal Mouse Anti-Human
CD138
Clone MI15
CD138, syndecan-1, is a transmembrane proteoglycan with a main cellular expression in stratified and simple epithelia. Within the hemopoietic system, CD138 is mainly confined to late stages of B-cell differentiation (1). CD138 expression is reduced during malignant transformation of various epithelia, and CD138 is rapidly shed by myeloma cells entering into apoptosis, making CD138 a marker of viable myeloma cells (2).
Isotype IgG1, kappa
References
- Jourdan M, Ferlin M, Legouffe E, Horvathova M, Liautard J, Rossi JF, et al. The myeloma cell antigen syndecan-1 is lost by apoptotic myeloma cells. Br J Haematol 1988;100:637-46.
- Costes V, Magen V, Legouffe E, Durand L, Baldet P, Rossi J-F, et al. The MI15 monoclonal antidody (anti-syndecan-1) is a reliable marker for quantifying plasma cells in paraffin-embedded bone marrow biopsies. Hum Pathol 1999;30:1405-11.
| Product | Size |  | C7256 APC Purified
| 1 mL Product No. C725601 | | R7229 RPE. Purified
| 1 mL Product No. R722901 |
|---|
Synonym(s) for Antigen
syndecan-1