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Monoclonal Mouse Anti-Human
Cytokeratin 19
Clone RCK108
Reacts with the 40 kDa protein corresponding to cytokeratin 19.
The antibody labels many types of normal and neoplastic simple and non-keratinizing epithelia, including ductal and glandular epithelia.
Isotype IgG1, kappa
- Frozen
- Formalin
- Enzyme/HIER
References
- Dalal P, Shousha S. Keratin 19 in paraffin sections of medullary carcinoma and other benign and malignant breast lesions. Mod Pathol 1995;8:413-6.
Breast carcinoma (FFPE) stained with FLEX Anti-Cytokeratin 19, Code IR615/IS615.
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Breast carcinoma. The majority of the neoplastic cells show a strong cytoplasmic staining reaction.
Clinical application for IR615/IS615. For identification of epithelial tumors with cytokeration 19 (CK 19)-expression such as breast carcinoma, thyroid papillary carcinoma and cholangiocarcinoma.
Thyroid papillary carcinoma. The neoplastic cells show a strong cytoplasmic staining reaction, whereas the adjacent normal thyroid is negative.
Clinical application for IR615IS615. For identification of epithelial tumors with cytokeration 19 (CK 19)-expression such as breast carcinoma, thyroid papillary carcinoma and cholangiocarcinoma.
Liver. The bile duct epithelial cells show a moderate to strong cytoplasmic staining reaction, whereas the liver cells are negative.
Recommended control for IR615/IS615. Liver/Tonsil.
Tonsil. Focally, the squamous epithelial cells show a weak to moderate cytoplasmic staining reaction with the strongest staining in the basal layer.
Recommended control for IR615/IS615. Liver/Tonsil.
Disclaimer: Due to variances among color computer monitors, the colors you see on your screen may not be the exact colors of the stain. The image you see should be considered close renditions to the actual stain.
- Concentrated Antibody
for Manual Use - Ready-to-use Antibody
for Autostainer Link Instrument - Ready-to-use Antibody
for Autostainer Plus Instrument
- Excellent specificity
- High lot to lot consistency
- Optimized for immunohistochemistry (IHC) with validated protocols
- Certified manufacturing facilities guarantee full quality control
Intended Use
For in vitro diagnostic use.
Monoclonal Mouse Anti-Human Cytokeratin 19, Clone RCK108, is intended for use in immunohistochemistry. The antibody labels epithelial cells expressing the cytokeratin 19 protein, and is a useful tool for the identification of epithelial tumors, and may be useful in identifying cholangiocellular carcinomas (1). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
Monoclonal Mouse Anti-Human Cytokeratin 19, Clone RCK108, is intended for use in immunohistochemistry. The antibody labels epithelial cells expressing the cytokeratin 19 protein, and is a useful tool for the identification of epithelial tumors, and may be useful in identifying cholangiocellular carcinomas (1). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
Immunogen
Cytoskeletal preparation from human bladder cancer cell line T24 (1).
Specificity
In Western blotting of cytoskeleton preparations from the T24 and RT4 cell lines as well as the human squamous carcinoma cell line HaCaT, the antibody labels a single band of 40 kDa corresponding to CK 19 (1).
In immunohistochemistry on different human tissues, the antibody labels only epithelia, whereas cells known not to contain CK 19, e.g. hepatocytes, are not labeled (1).
In immunohistochemistry on different human tissues, the antibody labels only epithelia, whereas cells known not to contain CK 19, e.g. hepatocytes, are not labeled (1).
Reagent Provided
Monoclonal mouse antibody provided in liquid form as cell culture supernatant dialysed against 0.05 mol/L Tris/HCl, pH 7.2, and containing 15 mmol/L NaN3.
Clone: RCK108 (1). Isotype: IgG1, kappa.
Mouse IgG concentration: See label on vial.
The protein concentration between lots may vary without influencing the optimal dilution. The titer of each individual lot is compared and adjusted to a reference lot to ensure a consistent immunohistochemical staining performance from lot-to-lot.
Clone: RCK108 (1). Isotype: IgG1, kappa.
Mouse IgG concentration: See label on vial.
The protein concentration between lots may vary without influencing the optimal dilution. The titer of each individual lot is compared and adjusted to a reference lot to ensure a consistent immunohistochemical staining performance from lot-to-lot.
References
- Kwaspen FHL, Smedts FMM, Broos A, Bulten H, Debie WMH et al. Reproducible and highly sensitive detection of the broad spectrum epithelial marker keratin 19 in routine cancer diagnosis. Histopathol 1997;31:503-16.
| Product | Size |  | M0888 Culture supernatant
| 1 mL Product No. M088801 |
|---|
- Optimized staining performance of both high- and low-expression structures
- Crisp and clear staining with no background
- Optimal laboratory efficiency with ready-to-use antibodies on Dako Autostainer Link 48
Intended Use
For in vitro diagnostic use.
FLEX Monoclonal Mouse Anti-Human Cytokeratin 19, Clone RCK108, Ready-to-Use (Link), is intended for use in immunohistochemistry together with Autostainer Link instruments. This antibody labels epithelial cells expressing the cytokeratin 19 protein, and is useful for the identification of epithelial tumors, and may be useful in identifying cholangiocellular carcinomas (1). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
FLEX Monoclonal Mouse Anti-Human Cytokeratin 19, Clone RCK108, Ready-to-Use (Link), is intended for use in immunohistochemistry together with Autostainer Link instruments. This antibody labels epithelial cells expressing the cytokeratin 19 protein, and is useful for the identification of epithelial tumors, and may be useful in identifying cholangiocellular carcinomas (1). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
Immunogen
Cytoskeletal preparation from human bladder cancer cell line T24 (1).
Specificity
In Western blotting of cytoskeleton preparations from the T24 and RT4 cell lines as well as the human squamous carcinoma cell line HaCaT, the antibody labels a single band corresponding to CK19 (1).
In immunohistochemistry on different human tissues, the antibody labels only epithelia, whereas cells known not to contain CK19, e.g. hepatocytes, are not labeled (1).
In immunohistochemistry on different human tissues, the antibody labels only epithelia, whereas cells known not to contain CK19, e.g. hepatocytes, are not labeled (1).
Reagent Provided
Ready-to-use monoclonal mouse antibody provided in liquid form in a buffer containing stabilizing protein and 0.015 mol/L sodium azide.
Clone: RCK108. Isotype: IgG1, kappa.
Clone: RCK108. Isotype: IgG1, kappa.
References
- Kwaspen FHL, Smedts FMM, Broos A, Bulten H, Debie WMH et al. Reproducible and highly sensitive detection of the broad spectrum epithelial marker keratin 19 in routine cancer diagnosis. Histopathol 1997;31:503-16.
| Product | Size | | IR615 RTU, FLEX
| 60 tests, 12 mL Product No. IR61561 |
|---|
- Optimized staining performance of both high- and low-expression structures
- Crisp and clear staining with no background
- Optimal laboratory efficiency with ready-to-use antibodies on Dako Autostainer Plus
Intended Use
For in vitro diagnostic use.
FLEX Monoclonal Mouse Anti-Human Cytokeratin 19, Clone RCK108, Ready-to-Use (Dako Autostainer/Autostainer Plus), is intended for use in immunohistochemistry together with Dako Autostainer/Autostainer Plus instruments. This antibody labels epithelial cells expressing the cytokeratin 19 protein, and is useful for the identification of epithelial tumors, and may be useful in identifying cholangiocellular carcinomas (1). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
FLEX Monoclonal Mouse Anti-Human Cytokeratin 19, Clone RCK108, Ready-to-Use (Dako Autostainer/Autostainer Plus), is intended for use in immunohistochemistry together with Dako Autostainer/Autostainer Plus instruments. This antibody labels epithelial cells expressing the cytokeratin 19 protein, and is useful for the identification of epithelial tumors, and may be useful in identifying cholangiocellular carcinomas (1). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
Immunogen
Cytoskeletal preparation from human bladder cancer cell line T24 (1).
Specificity
In Western blotting of cytoskeleton preparations from the T24 and RT4 cell lines as well as the human squamous carcinoma cell line HaCaT, the antibody labels a single band corresponding to CK19 (1).
In immunohistochemistry on different human tissues, the antibody labels only epithelia, whereas cells known not to contain CK19, e.g. hepatocytes, are not labeled (1).
In immunohistochemistry on different human tissues, the antibody labels only epithelia, whereas cells known not to contain CK19, e.g. hepatocytes, are not labeled (1).
Reagent Provided
Ready-to-use monoclonal mouse antibody provided in liquid form in a buffer containing stabilizing protein and 0.015 mol/L sodium azide.
Clone: RCK108. Isotype: IgG1, kappa.
Clone: RCK108. Isotype: IgG1, kappa.
References
- Kwaspen FHL, Smedts FMM, Broos A, Bulten H, Debie WMH et al. Reproducible and highly sensitive detection of the broad spectrum epithelial marker keratin 19 in routine cancer diagnosis. Histopathol 1997;31:503-16.
| Product | Size | | IS615 RTU, FLEX
| 30 tests, 6 mL Product No. IS61530 |
|---|
Synonym(s) for Antigen
CK19, keratin