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Monoclonal Mouse Anti-Human
B-Cell-Specific Activator Protein
Clone DAK-Pax5
B-cell-specific activator protein, BSAP, also known as Pax-5, is a transcription factor expressed in B cells.
Antibodies to BSAP may be useful for the identification of pro, pre, and mature B cells and in the classification of lymphomas. Together with a panel of antibodies it is particularly useful in the differential identification of classic Hodgkin's disease versus anaplastic large cell lymphoma of the T and null-cell type.
Isotype IgG1, kappa
- Frozen
- Formalin
- HIER
Hodgkin's lymphoma (FFPE) stained with FLEX Anti-BSAP, Code IR650/IS650.
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Hodgkin's lymphoma. The Reed-Sternberg cells show a weak to moderate nuclear staining reaction.
Clinical application for IR650/IS650. For identification of pro/pre B cells, mature B cells and in the classification of lymphomas
B-cell chronic lymphatic leukemia/small lymphocytic lymphoma. The majority of the neoplastic cells show a moderate to strong nuclear staining reaction.
Clinical application for IR650/IS650. For identification of pro/pre B cells, mature B cells and in the classification of lymphomas
Tonsil. The B cells in the mantle zone and in the germinal center show a moderate to strong nuclear staining reaction. The germinal center B cells also show a weak cytoplasmic staining reaction. No staining reaction should be seen in plasma cells or in the squamous epithelial cells.
Recommended control for IR650/IS650. Tonsil.
Hodgkin's lymphoma stained with Anti-BSAP.
Clinical application for IR650/IS650. For identification of pro/pre B cells, mature B cells and in the classification of lymphomas
Disclaimer: Due to variances among color computer monitors, the colors you see on your screen may not be the exact colors of the stain. The image you see should be considered close renditions to the actual stain.
- Concentrated Antibody
for Manual Use - Ready-to-use Antibody
for Autostainer Link Instrument - Ready-to-use Antibody
for Autostainer Plus Instrument
- Excellent specificity
- High lot to lot consistency
- Optimized for immunohistochemistry (IHC) with validated protocols
- Certified manufacturing facilities guarantee full quality control
Intended Use
For in vitro diagnostic use.
Monoclonal Mouse Anti-Human B-Cell-Specific Activator Protein, Clone DAK-Pax5, is intended for use in immunohistochemistry. Antibodies to B-cell-specific activator protein (BSAP) may be useful for the identification of pro-, pre-, and mature B cells and in the classification of lymphomas (1-4). Together with a panel of antibodies it is particularly useful in the differential identification of classic Hodgkin's disease versus anaplastic large cell lymphoma of T- and null-cell type (1, 3). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
Monoclonal Mouse Anti-Human B-Cell-Specific Activator Protein, Clone DAK-Pax5, is intended for use in immunohistochemistry. Antibodies to B-cell-specific activator protein (BSAP) may be useful for the identification of pro-, pre-, and mature B cells and in the classification of lymphomas (1-4). Together with a panel of antibodies it is particularly useful in the differential identification of classic Hodgkin's disease versus anaplastic large cell lymphoma of T- and null-cell type (1, 3). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
Immunogen
Synthetic 17-meric peptide from the C-terminal inhibitory domain of the protein.
Specificity
In Western blotting of mouse spleen cell lysate, the antibody labels a 55 kDa protein corresponding to BSAP.
Reagent Provided
Monoclonal mouse antibody provided in liquid form as cell culture supernatant dialyzed against 0.05 mol/L Tris/HCl, pH 7.2, and containing 0.015 mol/L sodium azide.
Clone: DAK-Pax5. Isotype: IgG1, kappa.
Mouse IgG concentration mg/L: See label on vial.
The protein concentration between lots may vary without influencing the optimal dilution. The titer of each individual lot is compared and adjusted to a reference lot to ensure a consistent immunohistochemical staining performance from lot-to-lot.
Clone: DAK-Pax5. Isotype: IgG1, kappa.
Mouse IgG concentration mg/L: See label on vial.
The protein concentration between lots may vary without influencing the optimal dilution. The titer of each individual lot is compared and adjusted to a reference lot to ensure a consistent immunohistochemical staining performance from lot-to-lot.
References
- Browne P, Petrosyan K, Hernandez A, Chan JA. The B-cell transcription factors BSAP, Oct-2, and BOB.1 and the pan-B-cell markers CD20, CD22 and CD79a are useful in the differential diagnosis of classic Hodgkin lymphoma. Am J Clin Pathol 2003;120:767-77.
- Krenacs L, Himmelmann AW, Quintanilla-Martinez L, Fest T, Riva A, Wellmann A, et al. Transcription factor B-cell-specific activator protein (BSAP) is differentially expressed in B cells and in subsets of B-cell lymphomas. Blood 1998;92:1308-16.
- Torlakovic E, Torlakovic G, Nguyen PL, Brunning RD, Delabie J. The value of anti-pax-5 immunostaining in routinely fixed and paraffin-embedded sections: a novel pan pre-B and B-cell marker. Am J Surg Pathol 2002;26:1343-50.
- Zhang X, Lin Z, Kim I. Pax5 expression in non-Hodgkin's lymphomas and acute leukemias. J Korean Med Sci 2003;18:804-8.
| Product | Size |  | M7307 Culture supernatant
| 0.2 mL Product No. M730729 |
|---|---|---|
| 1 mL Product No. M730701 |
- Optimized staining performance of both high- and low-expression structures
- Crisp and clear staining with no background
- Optimal laboratory efficiency with ready-to-use antibodies on Dako Autostainer Link 48
Intended Use
For in vitro diagnostic use.
FLEX Monoclonal Mouse Anti-Human B-Cell-Specific Activator Protein, Clone DAK-Pax5, Ready-to-Use (Link), is intended for use in immunohistochemistry together with Autostainer Link instruments. Antibodies to B-cell-specific activator protein (BSAP) may be useful for the identification of pro-, pre-, and mature B cells and in the classification of lymphomas (1-4). Together with a panel of antibodies it is particularly useful in the differential identification of classic Hodgkin's disease versus anaplastic large cell lymphoma of T- and null-cell type (1, 3). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
FLEX Monoclonal Mouse Anti-Human B-Cell-Specific Activator Protein, Clone DAK-Pax5, Ready-to-Use (Link), is intended for use in immunohistochemistry together with Autostainer Link instruments. Antibodies to B-cell-specific activator protein (BSAP) may be useful for the identification of pro-, pre-, and mature B cells and in the classification of lymphomas (1-4). Together with a panel of antibodies it is particularly useful in the differential identification of classic Hodgkin's disease versus anaplastic large cell lymphoma of T- and null-cell type (1, 3). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
Immunogen
Synthetic 17-meric peptide from the C-terminal inhibitory domain of the protein.
Specificity
In Western blotting of mouse spleen cell lysate, the antibody labels a 55 kDa protein corresponding to BSAP.
Reagent Provided
Ready-to-use monoclonal mouse antibody provided in liquid form in a buffer containing stabilizing protein and 0.015 mol/L sodium azide.
Clone: DAK-Pax5. Isotype: IgG1, kappa.
Clone: DAK-Pax5. Isotype: IgG1, kappa.
References
- Browne P, Petrosyan K, Hernandez A, Chan JA. The B-cell transcription factors BSAP, Oct-2, and BOB.1 and the pan-B-cell markers CD20, CD22 and CD79a are useful in the differential diagnosis of classic Hodgkin lymphoma. Am J Clin Pathol 2003;120:767-77.
- Krenacs L, Himmelmann AW, Quintanilla-Martinez L, Fest T, Riva A, Wellmann A, et al. Transcription factor B-cell-specific activator protein (BSAP) is differentially expressed in B cells and in subsets of B-cell lymphomas. Blood 1998;92:1308-16.
- Torlakovic E, Torlakovic G, Nguyen PL, Brunning RD, Delabie J. The value of anti-pax-5 immunostaining in routinely fixed and paraffin-embedded sections: a novel pan pre-B and B-cell marker. Am J Surg Pathol 2002;26:1343-50.
- Zhang X, Lin Z, Kim I. Pax5 expression in non-Hodgkin's lymphomas and acute leukemias. J Korean Med Sci 2003;18:804-8.
| Product | Size | | IR650 RTU, FLEX
| 60 tests, 12 mL Product No. IR65061 |
|---|
- Optimized staining performance of both high- and low-expression structures
- Crisp and clear staining with no background
- Optimal laboratory efficiency with ready-to-use antibodies on Dako Autostainer Plus
Intended Use
For in vitro diagnostic use.
FLEX Monoclonal Mouse Anti-Human B-Cell-Specific Activator Protein, Clone DAK-Pax5, Ready-to-Use (Dako Autostainer/Autostainer Plus), is intended for use in immunohistochemistry together with Dako Autostainer/Autostainer Plus instruments. Antibodies to B-cell-specific activator protein (BSAP) may be useful for the identification of pro-, pre-, and mature B cells and in the classification of lymphomas (1-4). Together with a panel of antibodies it is particularly useful in the differential identification of classic Hodgkin's disease versus anaplastic large cell lymphoma of T- and null-cell type (1, 3). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
FLEX Monoclonal Mouse Anti-Human B-Cell-Specific Activator Protein, Clone DAK-Pax5, Ready-to-Use (Dako Autostainer/Autostainer Plus), is intended for use in immunohistochemistry together with Dako Autostainer/Autostainer Plus instruments. Antibodies to B-cell-specific activator protein (BSAP) may be useful for the identification of pro-, pre-, and mature B cells and in the classification of lymphomas (1-4). Together with a panel of antibodies it is particularly useful in the differential identification of classic Hodgkin's disease versus anaplastic large cell lymphoma of T- and null-cell type (1, 3). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
Immunogen
Synthetic 17-meric peptide from the C-terminal inhibitory domain of the protein.
Specificity
In Western blotting of mouse spleen cell lysate, the antibody labels a 55 kDa protein corresponding to BSAP.
Reagent Provided
Ready-to-use monoclonal mouse antibody provided in liquid form in a buffer containing stabilizing protein and 0.015 mol/L sodium azide.
Clone: DAK-Pax5. Isotype: IgG1, kappa.
Clone: DAK-Pax5. Isotype: IgG1, kappa.
References
- Browne P, Petrosyan K, Hernandez A, Chan JA. The B-cell transcription factors BSAP, Oct-2, and BOB.1 and the pan-B-cell markers CD20, CD22 and CD79a are useful in the differential diagnosis of classic Hodgkin lymphoma. Am J Clin Pathol 2003;120:767-77.
- Krenacs L, Himmelmann AW, Quintanilla-Martinez L, Fest T, Riva A, Wellmann A, et al. Transcription factor B-cell-specific activator protein (BSAP) is differentially expressed in B cells and in subsets of B-cell lymphomas. Blood 1998;92:1308-16.
- Torlakovic E, Torlakovic G, Nguyen PL, Brunning RD, Delabie J. The value of anti-pax-5 immunostaining in routinely fixed and paraffin-embedded sections: a novel pan pre-B and B-cell marker. Am J Surg Pathol 2002;26:1343-50.
- Zhang X, Lin Z, Kim I. Pax5 expression in non-Hodgkin's lymphomas and acute leukemias. J Korean Med Sci 2003;18:804-8.
| Product | Size | | IS650 RTU, FLEX
| 30 tests, 6 mL Product No. IS65030 |
|---|
Synonym(s) for Antigen
BSAP, Pax-5