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Monoclonal Mouse Anti-Human
Cytokeratin 19
Clone RCK108
Reacts with the 40 kDa protein corresponding to cytokeratin 19.
The antibody labels many types of normal and neoplastic simple and non-keratinizing epithelia, including ductal and glandular epithelia.
- Dalal P, Shousha S. Keratin 19 in paraffin sections of medullary carcinoma and other benign and malignant breast lesions. Mod Pathol 1995;8:413-6.
Thyroid papillary carcinoma (FFPE) stained with FLEX Anti-Cytokeratin 19, Code IR615/IS615.
Thyroid papillary carcinoma. The neoplastic cells show a strong cytoplasmic staining reaction, whereas the adjacent normal thyroid is negative.
Clinical application for IR615/S615. For identification of epithelial tumors with cytokeration 19 (CK 19)-expression such as breast carcinoma, thyroid papillary carcinoma and cholangiocarcinoma.
Disclaimer: Due to variances among color computer monitors, the colors you see on your screen may not be the exact colors of the stain. The image you see should be considered close renditions to the actual stain.
- Optimized staining performance of both high- and low-expression structures
- Crisp and clear staining with no background
- Optimal laboratory efficiency with ready-to-use antibodies on Dako Autostainer Link 48
FLEX Monoclonal Mouse Anti-Human Cytokeratin 19, Clone RCK108, Ready-to-Use (Link), is intended for use in immunohistochemistry together with Autostainer Link instruments. This antibody labels epithelial cells expressing the cytokeratin 19 protein, and is useful for the identification of epithelial tumors, and may be useful in identifying cholangiocellular carcinomas (1). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
In immunohistochemistry on different human tissues, the antibody labels only epithelia, whereas cells known not to contain CK19, e.g. hepatocytes, are not labeled (1).
Clone: RCK108. Isotype: IgG1, kappa.
- Kwaspen FHL, Smedts FMM, Broos A, Bulten H, Debie WMH et al. Reproducible and highly sensitive detection of the broad spectrum epithelial marker keratin 19 in routine cancer diagnosis. Histopathol 1997;31:503-16.
| Product | Size |  | IR615 Clone RCK108
| 60 tests, 12 mL Product No. IR61561 |
|---|
RECOMMENDED COMPANION PRODUCTS
| Step | Product | Size |
|---|---|---|
| Pre-treatment | EnVision™ FLEX Target Retrieval Solution, High pH (Code K8004) 3-in-1 procedure using PT Link | 3 x 30 mL Product No. K800421 |
| Antibody Dilution | Ready-to-use / Prediluted | |
| Negative Control | FLEX Negative Control, Mouse (Code IR750) Positive tissue: Liver and tonsil | 120 tests, 24 mL Product No. IR75066 |
| Visualization System | EnVision™ FLEX (Code K8000) Use High pH Target Retrieval Solution | 400-600 tests Product No. K800021 |
| Counterstain | Hematoxylin (Link) (Code K8008) Non-aqueous, permanent mounting medium is required | 3 x 45 mL, 400-600 tests Product No. K800821 |
| Glass Slides | FLEX IHC Microscope Slides (Code K8020) Recommended for greater adherence | 5 x 100 slides Product No. K802021 |