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Monoclonal Mouse Anti-Human
CD10
Clone 56C6
CD10 is a cell surface metallopeptidase, expressed on early lymphoid progenitor cells and on a small subset of immature B cells in bone marrow, but is lost as the cells reach maturation.
CD10 is, however, re-expressed on proliferating B cells and mature neutrophils. Various non-lymphoid cells, including bile canaliculi and renal glomerular and tubular epithelial cells are also CD10-positive. The antibody is useful for the identification of Burkitt's lymphoma, follicular lymphoma except grade III, precursor B-cell acute lymphoblastic leukemia, and clear cell renal cell carcinoma. Futhermore, CD10 may be a useful marker in the differential diagnosis of the mature T-cell neoplasia subtype, angioimmunoblastic T-cell lymphoma from other peripheral T-cell lymphomas.
Anti-CD10, Clone 56C6, is well-suited for use on formalin-fixed tissue sections.
- Ordi J, Romagosa C, Tavassoli FA, Nogales F, Palacin A, Condom E, et al. CD10 expression in epithelial tissue and tumors of the gynecologic tract. A useful marker in the diagnosis of mesonephric, trophoblastic, and clear cell tumors. Am J Surg Pathol 2003;27:178-86.
- Attygalle A, Al-Jehani R, Diss TC, Munson P, Liu H, Du M-Q, et al. Neoplastic T cells in angioimmunoblastic T-cell lymphoma express CD10. Blood 2002;99:627-33.
Precursor B-lymphoblastic lymphoma (FFPE) stained with FLEX Anti-CD10, Code IR648/IS648.
Precursor B-cell lymphoblastic leukemia/lymphoma. The neoplastic cells show a strong membranous staining reaction.
Clinical application for IR648/IS648. For identification of Burkitt lymphoma/leukemia, follicular lymphoma (except grade III), precursor B-cell lymphoblastic leukemia/lymphoma and renal cell carcinoma of the clear cell type.
Disclaimer: Due to variances among color computer monitors, the colors you see on your screen may not be the exact colors of the stain. The image you see should be considered close renditions to the actual stain.
- Optimized staining performance of both high- and low-expression structures
- Crisp and clear staining with no background
- Optimal laboratory efficiency with ready-to-use antibodies on Dako Autostainer Link 48
FLEX Monoclonal Mouse Anti-Human CD10, Clone 56C6, Ready-to-Use (Link), is intended for use in immunohistochemistry together with Autostainer Link instruments. This antibody is useful for the identification of Burkitt lymphoma (1, 2), follicular lymphoma (1, 3, 4) except grade III (5), precursor B-cell acute lymphoblastic leukemia (1, 2), renal carcinoma - clear cell type (6, 7). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
Clone: 56C6. Isotype: IgG1, kappa.
- Kaufamann O, Flath B, Späth-Swalbe, Possinger K and Dietel M. Immunohistochemical detection of CD10 with monoclonal antibody 56C6 on paraffin sections. Am J Clin Pathol 1999;11:117-22.
- Chu PG, Chang KL, Weiss LM and Arber DA. Immunohistochemical detection of CD10 in paraffin sections of hematopoietic neoplasms. App Imm &Mol Morphol. 2000;8:257-62.
- Chen CC, Raikow RB, Sonmez-Alpan E and Swerdlow S. Classification of small B-cell lymphoid neoplasms using a paraffin section immunohistochemical panel. App Imm &Mol Morphol 2000;8:1-11.
- Lorsbach RB, Shay-Seymore D, Moore J, Banks PM, Hasserjian RP, Sandlund JT and Behm FG. Clinicopathologic analysis of follicular lymphoma occurring in children. Blood 2002;99:1959-64.
- Chu P and Arber DA. Paraffin section detection of CD10 in 505 nonhematopoietic neoplasms. Frequent expression in renal cell carcinoma and endometrial stromal sarcoma. Am J Clin Patholl 2000;113:374-82.
- Ordi J, Romagosa C, Tavassoli FA, Nogales F, Palacin A, Condom E, et al. CD10 expression in epithelial tissue and tumors of the gynecologic tract. A useful marker in the diagnosis of mesonephric, trophoblastic, and clear cell tumors. Am J Surg Pathol 2003;27:178-86.
- McIntosh GG, Lodge AJ, Watson P, Hall AG, Wood K, Anderson JJ et al. NCL-CD10-270: A new monoclonal antibody recognizing CD10 in paraffin-embedded tissue. Am J Pathol 1999;154:77-82.
| Product | Size |  | IR648 Clone 56C6
| 60 tests, 12 mL Product No. IR64861 |
|---|
RECOMMENDED COMPANION PRODUCTS
| Step | Product | Size |
|---|---|---|
| Pre-treatment | EnVision™ FLEX Target Retrieval Solution, High pH (Code K8004) 3-in-1 procedure using PT Link | 3 x 30 mL Product No. K800421 |
| Antibody Dilution | Ready-to-use / Prediluted | |
| Negative Control | FLEX Negative Control, Mouse (Code IR750) Positive tissue: Liver and tonsil | 120 tests, 24 mL Product No. IR75066 |
| Visualization System | EnVision™ FLEX (Code K8000) Use High pH Target Retrieval Solution | 400-600 tests Product No. K800021 |
| Counterstain | Hematoxylin (Link) (Code K8008) Non-aqueous, permanent mounting medium is required | 3 x 45 mL, 400-600 tests Product No. K800821 |
| Glass Slides | FLEX IHC Microscope Slides (Code K8020) Recommended for greater adherence | 5 x 100 slides Product No. K802021 |