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Monoclonal Mouse Anti-Human
Chromogranin A
Clone DAK-A3
Labels normal cells and neoplasms of neuroendocrine origin. Anti-Chromogranin A, clone DAK-A3, reacts with an epitope on the C-terminal half of the chromogranin A molecule.
Isotype IgG2b, kappa
- Frozen
- Formalin
- HIER
- Excellent specificity
- High lot to lot consistency
- Optimized for immunohistochemistry (IHC) with validated protocols
- Certified manufacturing facilities guarantee full quality control
Intended Use
For in vitro diagnostic use.
Monoclonal Mouse Anti-Human Chromogranin A, Clone DAK-A3, is intended for use in immunocytochemistry. The antibody labels chromogranin A present in secretory granules of endocrine cells. Chromogranin A is a marker for neuroendocrine differentiation and antibodies to chromogranin A are a useful tool for the identification of neuroendocrine-derived tumours. Differential identification is aided by the results from a panel of antibodies. Interpretation must be made within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
Monoclonal Mouse Anti-Human Chromogranin A, Clone DAK-A3, is intended for use in immunocytochemistry. The antibody labels chromogranin A present in secretory granules of endocrine cells. Chromogranin A is a marker for neuroendocrine differentiation and antibodies to chromogranin A are a useful tool for the identification of neuroendocrine-derived tumours. Differential identification is aided by the results from a panel of antibodies. Interpretation must be made within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
Immunogen
The C-terminal 20 kDa fragment of human chromogranin A corresponding to amino acids 210-439. The fragment has been isolated from the urine of patients with carcinoid syndrome, and was pure as shown by N-terminal amino acid analysis.
Specificity
In ELISA, the antibody reacts with the pure chromogranin A fragment used for immunization.
In immunocytochemistry the antibody shows a staining pattern essentially as that of an established polyclonal antibody to chromogranin A, Dako Code A0430, when tested on 84 different tumours and 30 different normal tissues. The labelling corresponds to the known distribution of chromogranin A. In addition, labelling of melanin and lipofucsin pigment was observed with both antibodies as also with an unrelated monoclonal antibody to chromogranin A, Clone LK2H10, after demasking of antigens with citrate buffer.
In immunocytochemistry the antibody shows a staining pattern essentially as that of an established polyclonal antibody to chromogranin A, Dako Code A0430, when tested on 84 different tumours and 30 different normal tissues. The labelling corresponds to the known distribution of chromogranin A. In addition, labelling of melanin and lipofucsin pigment was observed with both antibodies as also with an unrelated monoclonal antibody to chromogranin A, Clone LK2H10, after demasking of antigens with citrate buffer.
Reagent Provided
Monoclonal mouse antibody provided in liquid form as cell culture supernatant dialysed against 50 mmol/L Tris/HCl, pH 7.2, and containing 15 mmol/L NaN3.
Clone: DAK-A3. Isotype: IgG2b, kappa.
Mouse IgG concentration: see label on vial.
Clone: DAK-A3. Isotype: IgG2b, kappa.
Mouse IgG concentration: see label on vial.
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| Product | Size |  | M0869 Culture supernatant
| 0.2 mL Product No. M086929-2 |
|---|---|---|
| 1 mL Product No. M086901-2 |