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Monoclonal Mouse Anti-Human
Serotonin
Clone 5HT-H209
Reacts with serotonin in a broad range of normal, hyperplastic and neoplastic tissues. Serotonin is also called 5-hydroxytryptamine. The antibody is of particular importance in identifying primary and metastatic carcinoid tumors expressing serotonin.
Isotype IgG1, kappa
- Frozen
- Formalin
- Excellent specificity
- High lot to lot consistency
- Optimized for immunohistochemistry (IHC) with validated protocols
- Certified manufacturing facilities guarantee full quality control
Intended Use
For in vitro diagnostic use.
Monoclonal Mouse Anti-Human Serotonin, Clone 5HT-H209, is intended for use in immunocytochemistry. The antibody labels cells expressing serotonin. The antibody may be a useful tool for characterization of carcinoids (1-3). Differential identification is aided by the results from a panel of antibodies. Interpretation must be made within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
Monoclonal Mouse Anti-Human Serotonin, Clone 5HT-H209, is intended for use in immunocytochemistry. The antibody labels cells expressing serotonin. The antibody may be a useful tool for characterization of carcinoids (1-3). Differential identification is aided by the results from a panel of antibodies. Interpretation must be made within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
Immunogen
5-hydroxytryptamine hydrochloride.
Specificity
In immunocytochemistry the antibody labels entero-chromaffine (EC) cells in colon.
As demonstrated by immunocytochemistry, the antibody cross-reacts with the serotonin-equivalent molecule in guinea pig (4), mouse (7) and rat (8).
As demonstrated by immunocytochemistry, the antibody cross-reacts with the serotonin-equivalent molecule in guinea pig (4), mouse (7) and rat (8).
Reagent Provided
Monoclonal mouse antibody provided in liquid form as cell culture supernatant dialysed against 0.05 mol/L Tris/HCl, pH 7.2, and containing 15 mmol/L NaN3.
Clone: 5HT-H209. Isotype: IgG1, kappa.
Mouse IgG concentration: See label on vial.
Clone: 5HT-H209. Isotype: IgG1, kappa.
Mouse IgG concentration: See label on vial.
References
- Torske KR, Thompson LDR. Adenoma versus carcinoid tumor of the middle ear: a study of 48 cases and review of the literature. Mod Pathol 2002;15:543-55.
- Menezes G, Wakely P. Aspiration cytopathology of middle-ear neuroendocrine carcinoma. Diagn Cytopathol 2001;25:168-71.
- Granberg D, Wilander E, Öberg K, Skogseid B. Prognostic markers in patients with typical bronchial carcinoid tumors. J Clin Endocrinol Metab 2000;85:3425-30.
- Suzuki A, Naruse S, Kitagawa M, Ishiguro H, Yoshikawa T, Ko SBH, et al. 5-hydroxytryptamine strongly inhibits fluid secretion in guinea pig pancreatic duct cells. J Clin Invest 2001;108:749-56.
- Batt J, Asa S, Fladd C, Rotin D. Pituitary, pancreatic and gut neuroendocrine defects in protein tyrosine phosphatase-sigma-deficient mice. Mol Endocrinol 2002;16:155-69.
- Date Y, Kojima M, Hosoda H, Sawaguchi A, Mondal MS, Suganuma T, et al. Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology 2000;141:4255-61.
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| Product | Size |  | M0758 Culture supernatant
| 1 mL Product No. M075801-2 |
|---|
Synonym(s) for Antigen
5HT, 5-hydroxytryptamine