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Monoclonal Mouse Anti-Human
Mammaglobin
Clone 304-1A5
Mammaglobin, a 93-amino acid glycoprotein, is encoded by a gene first identified in a study directed at the isolation of novel human breast cancer-associated genes (1).
Mammaglobin expression is mostly, although not exclusively, confined to breast tissue, and anti-mammoglobin is, together with a panel of other antibodies, useful for the identification and classification of carcinomas of breast origin.
- Watson MA, Dintzis S, Darrow CM, Voss LE, DiPersio J, Jensen R, et al. Mammaglobin expression in primary, metastatic, and occult breast cancer. Cancer Res 1999;59:3028-31.
Breast hyperplasia (FFPE) stained with FLEX Anti-Mammaglobin, Code IR074/IS074.
Breast hyperplasia. The ductal epithelial cells show a moderate to strong cytoplasmic staining reaction.
Recommended control for IR074/IS074. Breast hyperplasia/Skin.
Disclaimer: Due to variances among color computer monitors, the colors you see on your screen may not be the exact colors of the stain. The image you see should be considered close renditions to the actual stain.
- Optimized staining performance of both high- and low-expression structures
- Crisp and clear staining with no background
- Optimal laboratory efficiency with ready-to-use antibodies on Dako Autostainer Link 48
FLEX Monoclonal Mouse Anti-Human Mammaglobin, Clone 304-1A5, Ready-to-Use (Link), is intended for use in immunohistochemistry together with Autostainer Link instruments. This antibody is useful for the identification of mammaglobin expressing cells in normal and neoplastic tissues. The antibody may be useful for the identification of breast ductal carcinoma. The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
In ELISA no reaction was found with overlapping peptides corresponding to the mammaglobin sequence indicating a conformational epitope.
Clone: 304-1A5 (1). Isotype: IgG1, kappa
- Fanger GR, Houghton RL, Retter MW, Hendrickson RC, Babcook J, Dillon DC, et al. Detection of mammaglobin in the sera of patients with breast cancer. Tumour Biol 2002; 23:212-21.
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| Product | Size |  | IR074 Clone 304-1A5
| 60 tests, 12 mL Product No. IR07461 |
|---|
RECOMMENDED COMPANION PRODUCTS
| Step | Product | Size |
|---|---|---|
| Pre-treatment | EnVision™ FLEX Target Retrieval Solution, High pH (Code K8004) 3-in-1 procedure using PT Link | 3 x 30 mL Product No. K800421-2 |
| Antibody Dilution | Ready-to-use / Prediluted | |
| Negative Control | FLEX Negative Control, Mouse (Code IR750) Positive tissue: Breast hyperplasia and skin | 120 tests, 24 mL Product No. IR75066 |
| Visualization System | EnVision™ FLEX (Code K8000) Use High pH Target Retrieval Solution | 400-600 tests Product No. K800021 |
| Counterstain | Hematoxylin (Link) (Code K8008) Non-aqueous, permanent mounting medium is required | 3 x 45 mL, 400-600 tests Product No. K800821 |
| Glass Slides | Silanized Slides (Code S3003) Recommended for greater adherence Alternative is FLEX IHC Microscope Slides (Code K8020) | 100 slides Product No. S300330-2 |