Polyclonal Rabbit Anti-Human

Calcitonin

Calcitonin is a 32 amino acid peptide hormone, produced in the parafollicular C cells of the thyroid.

Calcitonin acts through its receptors, causing osteoclast-mediated bone resorption and calcium excretion by the kidney. The antibody is useful for the identification of calcitonin-producing C cells, from which medullary thyroid carcinoma originates.

Thyroid medullary carcinoma (FFPE) stained with FLEX Anti-Calcitonin, Code IR515/IS515.

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Thyroid medullary carcinoma. The neoplastic cells show a strong staining reaction for calcitonin.

Clinical application for IR515/IS515. For identification of thyroid medullary carcinoma and thyroid C cells.

Disclaimer: Due to variances among color computer monitors, the colors you see on your screen may not be the exact colors of the stain. The image you see should be considered close renditions to the actual stain.

  • Optimized staining performance of both high- and low-expression structures
  • Crisp and clear staining with no background
  • Optimal laboratory efficiency with ready-to-use antibodies on Dako Autostainer Plus
The staining performance of all antibodies has been defined, tested and approved through collaboration with leading international pathologists. Check the Atlas of Stains - a guide to diagnostic accuracy

Intended Use
For in vitro diagnostic use.

FLEX Polyclonal Rabbit Anti-Human Calcitonin, Ready-to-Use (Dako Autostainer/Autostainer Plus), is intended for use in immunohistochemistry together with Dako Autostainer/Autostainer Plus instruments. This antibody is useful for the identification of calcitonin-producing C-cells, from which medullary thyroid carcinoma (MTC) originates (1). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
Immunogen
Synthetic human calcitonin, aa 1-32, coupled to bovine serum albumin (BSA).
Specificity
The antibody reacts with human calcitonin. Traces of contaminating antibodies have been removed by solid-phase absorption with human plasma and bovine serum proteins.

The antibody labels human thyroid C-cells, and other calcitonin-containing cells strongly and specifically. No non-specific staining has been observed.
Reagent Provided
Ready-to-use polyclonal rabbit antibody provided in liquid form in a buffer containing stabilizing protein and 0.015 mol/L NaN3.
References
  1. Hayashida CY, Alves VAF, Kanamura CT, Ezabella CL, Abelin NM, Nicolau W, et al. Immunohisto-chemistry of medullary thyroid carcinoma and C-cell hyperplasia by an affinity-purified anti-human calcitonin antiserum. Cancer 1993;72:1356-63.
ProductSize
This product is CE-marked according to the EU IVD Directive 98/79/ECIS515
Specification Sheet
Safety Data Sheet:
Non-hazard classification statement
30 tests, 6 mL
Product No. IS51530-2

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