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Monoclonal Mouse Anti-Human
Follicular Dendritic Cell
Clone CNA.42
Recognizes a non-lineage restricted 120 kDa antigen expressed on follicular dendritic cells. In malignant lymphomas, follicular dendritic cells, either forming network or scattered among malignant cells, are detected by the antibody. In particular in follicular lymphomas, the follicular pattern is highlighted. In some T-cell lymphomas the malignant cells are stained by the antibody. Only a few cases of B-cell lymphomas react with the antibody. This antibody is useful for demonstrating follicular dendritic reticulum cell network in nodular, lymphocyte-predominant Hodgkin's disease. Follicular dendritic reticulum cell sarcoma and EBV-positive inflammatory pseudotumors of FDC origin are also positive. M7157 is a good supplement, or alternative, to Dako's Anti-Human CD21 and CD35 monoclonal antibodies (Codes M0784 and M0710) for the demonstration of follicular dendritic cells (1, 2).
Isotype IgM
- Formalin
- HIER
- Delsol G, Meggetto F, Brousset P, Cohen-Knafo E, Al Saati T, Rochaix P, et al. Relation of follicular dendritic reticulum cells to Reed-Sternberg cells of Hodgkin's disease with emphasis on the expression of CD21 antigen. Am J Pathol 1993;142:1729-38.
- Raymond I, Al Saati T, Tkaczuk J, Chittal S, Delsol G. CNA.42, a new monoclonal antibody directed against a fixative-resistant antigen of follicular dendritic reticulum cells. Am J Pathol 1997;151:1577-85.
Tonsil (FFPE) stained with Anti-Follicular Dendritic Cell, Code M7157.
Disclaimer: Due to variances among color computer monitors, the colors you see on your screen may not be the exact colors of the stain. The image you see should be considered close renditions to the actual stain.
- Excellent specificity
- High lot to lot consistency
- Optimized for immunohistochemistry (IHC) with validated protocols
- Certified manufacturing facilities guarantee full quality control
Monoclonal Mouse Anti-Human Follicular Dendritic Cell, Clone CNA.42, is intended for use in immunocytochemistry. The antibody labels a 120 kDa antigen expressed on follicular dendritic cells. The antibody may be a useful tool for the identification of follicular dendritic cells, either forming network or scattered among malignant cells, in reactive lymphoid tissue, follicular lymphomas and Hodgkin´s disease (1). Differential identification is aided by the results from a panel of antibodies. Interpretation must be made within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
As demonstrated by immunocytochemistry, the antibody cross-reacts with FDCs in bird, cat, cow, dog, goat, horse, monkey, mouse, rabbit, rat, sheep and swine (1).
Clone: CNA.42. Isotype: IgM, kappa.
Mouse IgG concentration: 1 See label on vial.
- Raymond I, Al Saati T, Tkaczuk J, Chittal S, Delsol G. CNA.42, a new monoclonal antibody directed against a fixative-resistant antigen of follicular dendritic reticulum cells. Am J Pathol 1997;151:1577-85.
| Product | Size |  | M7157 Culture supernatant
| 1 mL Product No. M715701 |
|---|
Synonym(s) for Antigen
follicular dendritic reticulum cell