Monoclonal Mouse Anti-Human

Beta-Catenin

Clone β-Catenin-1

Beta-catenin is an 88 kDa multifunctional protein playing an essential role in cell-cell adhesion by binding to the transmembrane protein, cadherin.

Beta-catenin is also involved in the regulation of gene expression as a mediator of the Wnt signaling pathway. The expression and intracellular localization of beta-catenin is altered in many types of cancers. Besides the reactivity with human beta-catenin, the M3539 antibody cross-reacts with mouse beta-catenin.

Isotype IgG1, kappa

  • Frozen
  • Formalin
  • HIER

Colon adenocarcinoma (FFPE) stained with FLEX Anti-Beta-Catenin, Code IR702/IS702.

Colon adenocarcinoma. Many of the neoplastic cells show a moderate to strong nuclear staining reaction, while the normal epithelial cells show a membranous staining reaction.

Clinical application for IR702/IS702. For identification of desmoid tumors, colorectal cancer and colon adenoma.

Colon adenoma. The majority of the dysplastic cells show a moderate to strong nuclear staining reaction with weaker costaining of cytoplasm.

Clinical application for IR702/IS702. For identification of desmoid tumors, colorectal cancer and colon adenoma.

Colon. The epithelial cells show a moderate to strong predominantly membranous staining reaction. A weak membranous reaction can be seen in scattered endothelial cells, satellite cells in peripheral nerves and in the follicular dendritic network in the germinal centers of lymph nodes.

Recommended control for IR702/IS702. Appendix/Colon/Liver.

Liver. The hepatocytes show a weak to moderate predominantly membranous staining reaction.

Recommended control for IR702/IS702. Appendix/Colon/Liver.

Colorectal adenocarcinoma stained with Anti-Beta-Catenin.

Clinical application for IR702/IS702. For identification of desmoid tumors, colorectal cancer and colon adenoma.

Disclaimer: Due to variances among color computer monitors, the colors you see on your screen may not be the exact colors of the stain. The image you see should be considered close renditions to the actual stain.

  • Excellent specificity
  • High lot to lot consistency
  • Optimized for immunohistochemistry (IHC) with validated protocols
  • Certified manufacturing facilities guarantee full quality control
Dako's products are the result of almost 50 years experience ensuring quality and innovation in antibodies and reagents: the genesis of the pathology lab of tomorrow.

ProductSize
This product is CE-marked according to the EU IVD Directive 98/79/ECM3539 Culture supernatant
Safety Data Sheet:
Non-hazard classification statement
1 mL
Product No. M353901

  • Optimized staining performance of both high and low-expression structures
  • Crisp and clear staining with no background
  • Optimal laboratory efficiency with ready-to-use antibodies on Autostainer Link 48
The staining performance of all antibodies has been defined, tested and approved through collaboration with leading international pathologists. Check the Atlas of Stains - a guide to diagnostic accuracy.

ProductSize
This product is CE-marked according to the EU IVD Directive 98/79/ECIR702 RTU, FLEX
Safety Data Sheet:
Non-hazard classification statement
60 tests, 12 mL
Product No. IR70261

RECOMMENDED COMPANION PRODUCTS

StepProductSize
Pre-treatmentEnVision™ FLEX Target Retrieval Solution, High pH (Code K8004)
3-in-1 procedure using PT Link
3 x 30 mL
Product No. K800421
Antibody Dilution
Ready-to-use / Prediluted
 
Negative ControlFLEX Negative Control, Mouse (Code IS750)
Positive tissue: Colon and liver
60 tests, 12 mL
Product No. IS75061
Visualization SystemEnVision™ FLEX (Code K8010)
Use High pH Target Retrieval Solution
400-600 tests
Product No. K801021
CounterstainHematoxylin (Dako Autostainer/Autostainer Plus) (Code K8018)
Non-aqueous, permanent mounting medium is required
10 x 13 mL, 400-600 tests
Product No. K801821
Glass SlidesFLEX IHC Microscope Slides (Code K8020)
Recommended for greater adherence
5 x 100 slides
Product No. K802021

  • Optimized staining performance of both high and low-expression structures
  • Crisp and clear staining with no background
  • Optimal laboratory efficiency with ready-to-use antibodies on Dako Autostainer Plus
The staining performance of all antibodies has been defined, tested and approved through collaboration with leading international pathologists. Check the Atlas of Stains - a guide to diagnostic accuracy.

ProductSize
This product is CE-marked according to the EU IVD Directive 98/79/ECIS702 RTU, FLEX
Safety Data Sheet:
Non-hazard classification statement
30 tests, 6 mL
Product No. IS70230

Synonym(s)

Betacatenin

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