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Monoclonal Mouse Anti-Human

Podoplanin

Clone D2-40

Identifies the ~38 kDa O-linked transmembrane sialoglycoprotein podoplanin, which is expressed in the endothelium of lymphatic capillaries, but not in the blood vasculature (1). Besides the expression in lymphatic endothelium, podoplanin is also found in a variety of other tissues, including mesothelial cells, reticular cells, follicular dendritic cells, ovarian and testicular germ cells (2). Anti-Podoplanin, Clone D2-40 labels lymphatic endothelium whereas it is unreactive with vascular endothelium. In neoplastic tissue, immunostaining of lymphatic endothelium by the antibody has been shown to be useful in identifying lymphatic invasion of primary tumors.

Isotype IgG1, kappa

  • Frozen
  • Formalin
  • HIER

Seminoma (FFPE) stained with FLEX Anti-Podoplanin, Code IR072/IS072.

Seminoma. The neoplastic cells and lymphatic endothelial cells show a strong membranous and cytoplasmic staining reaction.

Clinical application for IR072/IS072. For identification of lymphatic invasion in a variety of cancers and the differential diagnosis between epithelioid mesothelioma and lung adenocarcinoma.

Mesothelioma. The majority of the neoplastic cells show a moderate to strong membranous and cytoplasmic staining reaction.

Clinical application for IR072/IS072. For identification of lymphatic invasion in a variety of cancers and the differential diagnosis between epithelioid mesothelioma and lung adenocarcinoma.

Appendix. Cajal cells show a moderate to strong cytoplasmic staining reaction. Endothelial cells should be negative.

Recommended control for IR072/IS072. Appendix/Tonsil.

Tonsil. The lymphatic endothelial cells and basal epithelial cells show a moderate to strong cytoplasmic staining reaction.

Recommended control for IR072/IS072. Appendix/Tonsil.

Disclaimer: Due to variances among color computer monitors, the colors you see on your screen may not be the exact colors of the stain. The image you see should be considered close renditions to the actual stain.

  • Excellent specificity
  • High lot to lot consistency
  • Optimized for immunohistochemistry (IHC) with validated protocols
  • Certified manufacturing facilities guarantee full quality control
Dako's products are the result of almost 50 years experience ensuring quality and innovation in antibodies and reagents: the genesis of the pathology lab of tomorrow.

ProductSize
This product is CE-marked according to the EU IVD Directive 98/79/ECM3619 Culture supernatant
Safety Data Sheet:
Non-hazard classification statement
0.2 mL
Product No. M361929
1 mL
Product No. M361901

  • Optimized staining performance of both high and low-expression structures
  • Crisp and clear staining with no background
  • Optimal laboratory efficiency with ready-to-use antibodies on Autostainer Link 48
The staining performance of all antibodies has been defined, tested and approved through collaboration with leading international pathologists. Check the Atlas of Stains - a guide to diagnostic accuracy.

ProductSize
This product is CE-marked according to the EU IVD Directive 98/79/ECIR072 RTU, FLEX
Safety Data Sheet:
Non-hazard classification statement
60 tests, 12 mL
Product No. IR07261

RECOMMENDED COMPANION PRODUCTS

StepProductSize
Pre-treatmentEnVision™ FLEX Target Retrieval Solution, High pH (Code K8004)
3-in-1 procedure using PT Link
3 x 30 mL
Product No. K800421
Antibody Dilution
Ready-to-use / Prediluted
 
Negative ControlFLEX Negative Control, Mouse (Code IS750)
Positive tissue: Appendix and tonsil
60 tests, 12 mL
Product No. IS75061
Visualization SystemEnVision™ FLEX (Code K8010)
Use High pH Target Retrieval Solution
400-600 tests
Product No. K801021
CounterstainHematoxylin (Dako Autostainer/Autostainer Plus) (Code K8018)
Non-aqueous, permanent mounting medium is required
10 x 13 mL, 400-600 tests
Product No. K801821
Glass SlidesSilanized Slides (Code S3003)
Recommended for greater adherence
Alternative is FLEX IHC Microscope Slides (Code K8020)
100 slides
Product No. S300330

  • Optimized staining performance of both high and low-expression structures
  • Crisp and clear staining with no background
  • Optimal laboratory efficiency with ready-to-use antibodies on Dako Autostainer Plus
The staining performance of all antibodies has been defined, tested and approved through collaboration with leading international pathologists. Check the Atlas of Stains - a guide to diagnostic accuracy.

ProductSize
This product is CE-marked according to the EU IVD Directive 98/79/ECIS072 RTU, FLEX
Safety Data Sheet:
Non-hazard classification statement
30 tests, 6 mL
Product No. IS07230

Synonym(s)

D2-40, lymphatic endothelium marker

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