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Polyclonal Rabbit Anti-Human
Matrix Metalloproteinase 9 (MMP-9)
Reacts with matrix metalloproteinase 9 (MMP-9), which is a zinc-dependent endopeptidase that degrades the basement membrane and other structural components of the extracellular matrix. It is expressed predominantly by stromal cells, including polymorphonuclear cells and macrophages. In cancer tissue, stromal cell expression may be induced by tumor cell infiltration, whereas no expression is seen in the cancer cells. MMP-9 is believed to play a critical role in tumor invasion and metastasis in many types of cancer as well as in angiogenesis (1, 2).
- Formalin
- HIER
- Stamenkovic I. Extracellular matrix remodelling: the role of matrix metalloproteinases [review]. J Pathol 2003;200:448-64
- Egeblad M, Werb Z. New functions for the matrix metalloproteinases in cancer progression [review]. Nat Rev Cancer 2002;2:161-74.
Colon carcinoma (FFPE) stained with Anti-Matrix Metalloproteinase 9, Code A0150, using CSA II visualization system.
Disclaimer: Due to variances among color computer monitors, the colors you see on your screen may not be the exact colors of the stain. The image you see should be considered close renditions to the actual stain.
- Excellent specificity
- High lot to lot consistency
- Optimized for immunohistochemistry (IHC) with validated protocols
- Certified manufacturing facilities guarantee full quality control
Polyclonal Rabbit Anti-Human Matrix Metalloproteinase 9 is intended for use in immunohistochemistry. This antibody is useful for the identification of matrix metalloproteinase 9 (MMP-9) (1). Interpretation must be made within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
As demonstrated by immunohistochemistry on formalin-fixed, paraffin-embedded tissue, the antibody cross-reacts with the MMP-9-equivalent protein in cow, dog, horse, rat, and swine.
Protein concentration g/L: See label on vial.
- Illemann M, Bird N, Majeed A, Sehested M, Laerum OD, Lund LR, et al. MMP-9 is differentially expressed in primary human colorectal adenocarcinomas and their metastases. Mol Cancer Res 2006;4:293-302.
- Kjeldsen L, Bjerrum OW, Askaa J, Borregaard N. Subcellular localization and release of human neutrophil gelatinase, confirming the existence of separate gelatinase-containing granules. Biochem J 1992;287:603-10.
| Product | Size |  | A0150 Affinity isolated
| 0.2 mL Product No. A015029 |
|---|
Synonym(s) for Antigen
MMP-9, MMP9, gelatinase B