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Monoclonal Mouse Anti-Human
Renal Cell Carcinoma Marker
Clone SPM314
Reacts with renal cell carcinoma marker (gp200), a surface membrane glycoprotein.
The antigen is expressed on the brush border of proximal renal tubules and on the luminal surface of Bowman's capsule, as well as in parathyroid parenchymal cells and colloid of thyroid follicles. The antibody is useful for the identification of malignant cells from primary and metastatic renal cell carcinomas.
Isotype IgG2b, kappa
- Frozen
- Formalin
- HIER
Renal cell carcinoma (FFPE) stained with FLEX Anti-Renal Cell Carcinoma Marker, Code IR075/IS075.
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Renal cell carcinoma (clear cell type). The majority of the neoplastic cells show a moderate to strong predominantly membranous staining reaction.
Clinical application for IR075/IS075 For identification of renal cell carcinoma vs. non-renal cell tumors.
Kidney. The epithelial cells of the proximal tubules show a moderate to strong membranous and cytoplasmic staining reaction.
Recommended control for IR075/IS075. Kidney.
Renal cell carcinoma stained with Anti-Renal Cell Carcinoma Marker.
Clinical application for IR075/IS075 For identification of renal cell carcinoma vs. non-renal cell tumors.
Disclaimer: Due to variances among color computer monitors, the colors you see on your screen may not be the exact colors of the stain. The image you see should be considered close renditions to the actual stain.
- Concentrated Antibody
for Manual Use - Ready-to-use Antibody
for Autostainer Link Instrument - Ready-to-use Antibody
for Autostainer Plus Instrument
- Excellent specificity
- High lot to lot consistency
- Optimized for immunohistochemistry (IHC) with validated protocols
- Certified manufacturing facilities guarantee full quality control
Intended Use
For in vitro diagnostic use.
Monoclonal Mouse Anti-Human Renal Cell Carcinoma Marker, Clone SPM314, is intended for laboratory use in immunohistochemistry. Antibodies to renal cell carcinoma marker may be useful for the identification of renal cell carcinoma. The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
Monoclonal Mouse Anti-Human Renal Cell Carcinoma Marker, Clone SPM314, is intended for laboratory use in immunohistochemistry. Antibodies to renal cell carcinoma marker may be useful for the identification of renal cell carcinoma. The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
Immunogen
Microsomal fraction of human renal cortical tissue homogenate
Specificity
In Western blotting of Caki-1 cell lysate, the antibody labels a band of approximately 200 kDa corresponding to the expected molecular weight of renal cell carcinoma marker (6).
Reagent Provided
Monoclonal mouse antibody provided in liquid form as cell culture supernatant (containing fetal bovine serum) dialyzed against 0.02 mol/L PBS, pH 6.2, and containing 0.015 mol/L sodium azide.
Clone: SPM314. Isotype: IgG2b, kappa.
Mouse IgG concentration mg/L: See label on vial.
The protein concentration between lots may vary without influencing the optimal dilution. The titer of each individual lot is compared and adjusted to a reference lot to ensure a consistent immunohistochemical staining performance from lot-to-lot.
Clone: SPM314. Isotype: IgG2b, kappa.
Mouse IgG concentration mg/L: See label on vial.
The protein concentration between lots may vary without influencing the optimal dilution. The titer of each individual lot is compared and adjusted to a reference lot to ensure a consistent immunohistochemical staining performance from lot-to-lot.
References
- M3632 WB013007 Report On File.
| Product | Size |  | M3632 Culture supernatant
| 0.2 mL Product No. M363229 |
|---|---|---|
| 1 mL Product No. M363201 |
- Optimized staining performance of both high- and low-expression structures
- Crisp and clear staining with no background
- Optimal laboratory efficiency with ready-to-use antibodies on Dako Autostainer Link 48
Intended Use
For in vitro diagnostic use.
FLEX Monoclonal Mouse Anti-Human Renal Cell Carcinoma Marker, Clone SPM314, Ready-to-Use (Link), is intended for use in immunohistochemistry together with Autostainer Link instruments. This antibody is useful for the identification of renal cell carcinoma. The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
FLEX Monoclonal Mouse Anti-Human Renal Cell Carcinoma Marker, Clone SPM314, Ready-to-Use (Link), is intended for use in immunohistochemistry together with Autostainer Link instruments. This antibody is useful for the identification of renal cell carcinoma. The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
Immunogen
Microsomal fraction of human renal cortical tissue homogenate.
Specificity
In Western blotting of Caki-1 cell lysate, the antibody labels a band of approximately 200 kDa corresponding to the expected molecular weight of renal cell carcinoma marker.
Reagent Provided
Ready-to-use monoclonal mouse antibody provided in liquid form in a buffer containing stabilizing protein and 0.015 mol/L sodium azide.
Clone: SPM314. Isotype: IgG2b, kappa.
Clone: SPM314. Isotype: IgG2b, kappa.
| Product | Size | | IR075 RTU, FLEX
| 60 tests, 12 mL Product No. IR07561 |
|---|
RECOMMENDED COMPANION PRODUCTS
| Step | Product | Size |
|---|---|---|
| Pre-treatment | EnVision™ FLEX Target Retrieval Solution, Low pH (Code K8005) 3-in-1 procedure using PT Link | 3 x 30 mL Product No. K800521 |
| Antibody Dilution | Ready-to-use / Prediluted | |
| Negative Control | FLEX Negative Control, Mouse (Code IR750) Positive tissue: Kidney | 120 tests, 24 mL Product No. IR75066 |
| Visualization System | EnVision™ FLEX+ (Code K8002) Use Low pH Target Retrieval Solution | 400-600 tests Product No. K800221 |
| Counterstain | Hematoxylin (Link) (Code K8008) Non-aqueous, permanent mounting medium is required | 3 x 45 mL, 400-600 tests Product No. K800821 |
| Glass Slides | Silanized Slides (Code S3003) Recommended for greater adherence Alternative is FLEX IHC Microscope Slides (Code K8020) | 100 slides Product No. S300330 |
- Optimized staining performance of both high- and low-expression structures
- Crisp and clear staining with no background
- Optimal laboratory efficiency with ready-to-use antibodies on Dako Autostainer Plus
Intended Use
For in vitro diagnostic use.
FLEX Monoclonal Mouse Anti-Human Renal Cell Carcinoma Marker, Clone SPM314, Ready-to-Use (Dako Autostainer/Autostainer Plus), is intended for use in immunohistochemistry together with Dako Autostainer/Autostainer Plus instruments. This antibody is useful for the identification of renal cell carcinoma. The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
FLEX Monoclonal Mouse Anti-Human Renal Cell Carcinoma Marker, Clone SPM314, Ready-to-Use (Dako Autostainer/Autostainer Plus), is intended for use in immunohistochemistry together with Dako Autostainer/Autostainer Plus instruments. This antibody is useful for the identification of renal cell carcinoma. The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
Immunogen
Microsomal fraction of human renal cortical tissue homogenate.
Specificity
In Western blotting of Caki-1 cell lysate, the antibody labels a band of approximately 200 kDa corresponding to the expected molecular weight of renal cell carcinoma marker.
Reagent Provided
Ready-to-use monoclonal mouse antibody provided in liquid form in a buffer containing stabilizing protein and 0.015 mol/L sodium azide.
Clone: SPM314. Isotype: IgG2b, kappa.
Clone: SPM314. Isotype: IgG2b, kappa.
| Product | Size | | IS075 RTU, FLEX
| 30 tests, 6 mL Product No. IS07530 |
|---|
RECOMMENDED COMPANION PRODUCTS
| Step | Product | Size |
|---|---|---|
| Pre-treatment | EnVision™ FLEX Target Retrieval Solution, Low pH (Code K8005) 3-in-1 procedure using PT Link | 3 x 30 mL Product No. K800521 |
| Antibody Dilution | Ready-to-use / Prediluted | |
| Negative Control | FLEX Negative Control, Mouse (Code IS750) Positive tissue: Kidney | 60 tests, 12 mL Product No. IS75061 |
| Visualization System | EnVision™ FLEX+ (Code K8012) Use Low pH Target Retrieval Solution | 400-600 tests Product No. K801221 |
| Counterstain | Hematoxylin (Dako Autostainer/Autostainer Plus) (Code K8018) Non-aqueous, permanent mounting medium is required | 10 x 13 mL, 400-600 tests Product No. K801821 |
| Glass Slides | Silanized Slides (Code S3003) Recommended for greater adherence Alternative is FLEX IHC Microscope Slides (Code K8020) | 100 slides Product No. S300330 |
Synonym(s) for Antigen
gp200, RCC