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Monoclonal Mouse Anti-Human
CD2
Clone AB75
CD2 is a transmembrane glycoprotein that is considered a pan-T-cell antigen expressed on the majority of thymocytes and virtually all peripheral T lymphocytes.
Among neoplasms, the majority of precursor and post thymic lymphomas and leukemias show CD2 expression, while B-cell neoplasms usually do not. The antibody is especially useful for identification of peripheral T-cell lymphoma, anaplastic large cell lymphoma and precursor T-cell lymphoma.
Isotype IgG1, kappa
- Formalin
- HIER
Peripheral T-cell lymphoma (FFPE) stained with FLEX Anti-CD2, Code IR651/IS651.
Peripheral T-cell lymphoma. The majority of the neoplastic cells show a distinct predominantly membranous staining reaction.
Clinical application for IR651/IS651. For identification of normal T cells and related neoplasms such as precursor T-lymphoblastic leukemia/lymphoma, peripheral T-cell lymphoma and anaplastic large cell lymphoma.
Precursor T-lymphoblastic leukemia/lymphoma. The majority of the neoplastic cells show a distinct predominantly membranous staining reaction.
Clinical application for IR651/IS651. For identification of normal T cells and related neoplasms such as precursor T-lymphoblastic leukemia/lymphoma, peripheral T-cell lymphoma and anaplastic large cell lymphoma.
Tonsil. The crowded T cells in the T-zone show a moderate to strong membranous staining reaction, and the scattered T cells in the germinal center show a strong continuous membranous staining reaction.
Recommended control for IR651/IS651. Appendix/Colon/Tonsil.
Tonsil. The crowded T cells in the T-zone show a moderate to strong membranous staining reaction, and the scattered T cells in the germinal center show a strong continuous membranous staining reaction.
Recommended control for IR651/IS651. Appendix/Colon/Tonsil.
Disclaimer: Due to variances among color computer monitors, the colors you see on your screen may not be the exact colors of the stain. The image you see should be considered close renditions to the actual stain.
- Concentrated Antibody
for Manual Use - Ready-to-use Antibody
for Autostainer Link Instrument - Ready-to-use Antibody
for Autostainer Plus Instrument
- Excellent specificity
- High lot to lot consistency
- Optimized for immunohistochemistry (IHC) with validated protocols
- Certified manufacturing facilities guarantee full quality control
FLEX Monoclonal Mouse Anti-Human CD2, Clone AB75, is intended for use in immunohistochemistry. This antibody labels normal T cells and related neoplasms and is especially useful for the identification of precursor T-cell lymphoma (1), peripheral T-cell lymphoma (2) and anaplastic large cell lymphoma (3). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
Clone: AB75. Isotype: IgG1, kappa.
Mouse IgG concentration mg/L: See label on vial.
The protein concentration between lots may vary without influencing the optimal dilution. The titer of each individual lot is compared and adjusted to a reference lot to ensure a consistent immunohistochemical staining performance from lot-to-lot.
- Hyjek E, Chadburn A, Liu YF, Cesarman E, Knowles DM. BCL-6 protein is expressed in precursor T-cell lymphoblastic lymphoma and in prenatal and postnatal thymus. Blood 2001;97:270-76.
- Went P, Agostinelli C, Gallaminni A, Piccaluga PP, Ascani S, Sabattini E, et al. Marker expression in peripheral T-cell lymphoma: A proposed clinical-pathological prognostic score. J Clin Oncol 2006;24:2472-79.
- D'Amore SEG, Menin A, Bonoldi E, Bevilacqua P, Cazzavilan S, Donofrio V, et al. Anaplastic large cell lymphomas: A study of 75 pediatric patients. Pediatr Dev Pathol 2007;10:181-91.
| Product | Size |  | M7309 Culture supernatant
| 0.2 mL Product No. M730929 |
|---|---|---|
| 1 mL Product No. M730901 |
- Optimized staining performance of both high- and low-expression structures
- Crisp and clear staining with no background
- Optimal laboratory efficiency with ready-to-use antibodies on Dako Autostainer Link 48
FLEX Monoclonal Mouse Anti-Human CD2, Clone AB75, Ready-to-Use (Link), is intended for use in immunohistochemistry together with Autostainer Link instruments. This antibody labels normal T cells and related neoplasms and is especially useful for the identification of precursor T-cell lymphoma (1), peripheral T-cell lymphoma (2) and anaplastic large cell lymphoma (3). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
Clone: AB75. Isotype: IgG1, kappa.
- Hyjek E, Chadburn A, Liu YF, Cesarman E, Knowles DM. BCL-6 protein is expressed in precursor T-cell lymphoblastic lymphoma and in prenatal and postnatal thymus. Blood 2001;97:270-76.
- Went P, Agostinelli C, Gallaminni A, Piccaluga PP, Ascani S, Sabattini E, et al. Marker expression in peripheral T-cell lymphoma: A proposed clinical-pathological prognostic score. J Clin Oncol 2006;24:2472-79.
- D'Amore SEG, Menin A, Bonoldi E, Bevilacqua P, Cazzavilan S, Donofrio V, et al. Anaplastic large cell lymphomas: A study of 75 pediatric patients. Pediatr Dev Pathol 2007;10:181-91.
| Product | Size | | IR651 RTU, FLEX
| 60 tests, 12 mL Product No. IR65161 |
|---|
- Optimized staining performance of both high- and low-expression structures
- Crisp and clear staining with no background
- Optimal laboratory efficiency with ready-to-use antibodies on Dako Autostainer Plus
FLEX Monoclonal Mouse Anti-Human CD2, Clone AB75, Ready-to-Use (Dako Autostainer/Autostainer Plus), is intended for use in immunohistochemistry together with Dako Autostainer/Autostainer Plus instruments. This antibody labels normal T cells and related neoplasms and is especially useful for the identification of precursor T-cell lymphoma (1), peripheral T-cell lymphoma (2) and anaplastic large cell lymphoma (3). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
Clone: AB75. Isotype: IgG1, kappa.
- Hyjek E, Chadburn A, Liu YF, Cesarman E, Knowles DM. BCL-6 protein is expressed in precursor T-cell lymphoblastic lymphoma and in prenatal and postnatal thymus. Blood 2001;97:270-76.
- Went P, Agostinelli C, Gallaminni A, Piccaluga PP, Ascani S, Sabattini E, et al. Marker expression in peripheral T-cell lymphoma: A proposed clinical-pathological prognostic score. J Clin Oncol 2006;24:2472-79.
- D'Amore SEG, Menin A, Bonoldi E, Bevilacqua P, Cazzavilan S, Donofrio V, et al. Anaplastic large cell lymphomas: A study of 75 pediatric patients. Pediatr Dev Pathol 2007;10:181-91.
| Product | Size | | IS651 RTU, FLEX
| 30 tests, 6 mL Product No. IS65130 |
|---|
Synonym(s) for Antigen
LFA2, leucocyte function-associated antigen, T11 antigen, Tp50