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Monoclonal Rabbit Anti-Human

ERG (Ets-Related Gene)

Clone EP111

Ets-related gene (ERG) product is a ~41 kDa nuclear protein functioning as a DNA-binding transcriptional regulator that belongs to the erythroblast transformation-specific (ETS) family of transcription factors. In prostate cancer, ERG has most frequently been shown as a fusion protein with transmembrane protease, serine 2 (TMPRSS2), where a deletion between the TMPRSS2 and ERG genes causes the ERG gene to come under the control of the androgen-responsive promoter elements of TMPRSS2.
This antibody is useful for the identification of prostate adenocarcinoma (1, 2). Overexpression of ERG is associated with prostate cancer. Furthermore, ERG has been associated with prostatic intraepithelial neoplasia (PIN) and benign and malignant vascular endothelial cells in various different vascular tumors.

  • Formalin
  • HIER

Prostate adenocarcinoma (FFPE) stained with FLEX Anti-ERG, Code IR659.

Prostate adenocarcinoma. The majority of neoplastic cells show a moderate to strong nuclear staining reaction.

Clinical application for IR659. For identification of prostate adenocarcinoma. Overexpression of the ERG gene products is associated with prostate cancer.

Prostate adenocarcinoma. The majority of neoplastic cells show a moderate to strong nuclear staining reaction.

Clinical application for IR659. For identification of prostate adenocarcinoma. Overexpression of the ERG gene products is associated with prostate cancer.

Endothelial cells of the vascular system. Endothelial cells show a moderate to strong nuclear staining in virtually all tissues.

Recommended control for IR659. Endothelial cells of the vascular system in all tissues.

Disclaimer: Due to variances among color computer monitors, the colors you see on your screen may not be the exact colors of the stain. The image you see should be considered close renditions to the actual stain.

  • Excellent specificity
  • High lot to lot consistency
  • Optimized for immunohistochemistry (IHC) with validated protocols
  • Certified manufacturing facilities guarantee full quality control
Dako's products are the result of almost 50 years experience ensuring quality and innovation in antibodies and reagents: the genesis of the pathology lab of tomorrow.

ProductSize
This product is CE-marked according to the EU IVD Directive 98/79/ECM7314 Affinity isolated
Safety Data Sheet:
Non-hazard classification statement
0.2 mL
Product No. M731429
1 mL
Product No. M731401

RECOMMENDED COMPANION PRODUCTS

StepProductSize
Pre-treatmentEnVision™ FLEX Target Retrieval Solution, High pH (Code K8004)
3-in-1 procedure using PT Link
3 x 30 mL
Product No. K800421
Antibody DilutionAntibody Diluent (Code S0809)
Dilute 1:50
50 mL
Product No. S080981
125 mL
Product No. S080983
Negative ControlRabbit Immunoglobulin Fraction (Solid-Phase Absorbed) (Code X0936)
Positive tissue: Endothelial cells in all tissues
2 mL
Product No. X093602
Visualization SystemEnVision™ FLEX (Code K8000/K8010)
Use High pH Target Retrieval Solution
400-600 tests
Product No. K800021
CounterstainHematoxylin (Code K8008/K8018)
Non-aqueous, permanent mounting medium is required
3 x 45 mL, 400-600 tests
Product No. K800821
Glass SlidesFLEX IHC Microscope Slides (Code K8020)
Recommended for greater adherence to glass slides
5 x 100 slides
Product No. K802021
CounterstainHematoxylin (Link) (Code K8008)
Non-aqueous, permanent mounting medium is required
3 x 45 mL, 400-600 tests
Product No. K800821
Glass SlidesFLEX IHC Microscope Slides (Code K8020)
Recommended for greater adherence to glass slides
5 x 100 slides
Product No. K802021

  • Optimized staining performance of both high and low-expression structures
  • Crisp and clear staining with no background
  • Optimal laboratory efficiency with ready-to-use antibodies on Autostainer Link 48
The staining performance of all antibodies has been defined, tested and approved through collaboration with leading international pathologists. Check the Atlas of Stains - a guide to diagnostic accuracy.

ProductSize
This product is CE-marked according to the EU IVD Directive 98/79/ECIR659 RTU, FLEX
Safety Data Sheet:
Non-hazard classification statement
60 tests, 12 mL
Product No. IR65961

Synonym(s)

Ets-Related Gene, transcriptional regulator ERG, transforming protein ERG

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