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GenPoint™ HPV DNA Probe Cocktail, Biotinylated
GenPoint™ HPV Probe is an HPV probe cocktail that identifies the 13 most prevalent high-risk HPV genotypes, including types 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, and 68. GenPoint™ HPV Probe contains HPV genomic DNA in the form of double-stranded fragments of 500 base pairs or less (biotinylated and unlabeled), and multiple biotinylated oligonucleotides from 25 to 40 bases in length. The probe is provided in 1 mL of in situ hybridization solution.
GenPoint™ HPV Probe is optimized for amplified in situ hybridization using the GenPoint™ Tyramide Signal Amplification System, Code K0620, on histology and cytology specimens. The combination of this amplified ISH detection system and the GenPoint™ HPV Probe is the most powerful chromogenic ISH system available. The GenPoint™ System enables the sensitive detection of 1-2 copies of HPV DNA within the nucleus of an infected cell. This is demonstrated by a single punctate stain within the nucleus when observed under a bright field microscope. Episomal HPV DNA is represented by diffuse staining over the entire nucleus. The GenPoint™ assay is automated on the Dako Hybridizer and Autostainer Plus for optimal and reproducible performance.
Cervical biopsy, CIN II, stained with GenPoint™ HPV, Biotinylated DNA Probe Cocktail, Code Y1443. Episomal HPV DNA is evident by the complete nuclear staining pattern. Original diagnosis by H&E.
Cervical biopsy, CIN III, stained with GenPoint™ HPV, Biotinylated DNA Probe Cocktail, Code Y1443. Integrated HPV virus is denoted by the single punctate staining pattern. Original diagnosis by H&E.
ThinPrep® liquid-based cervical cytology specimen, LSIL, stained with GenPoint™ HPV, Biotinylated DNA Probe Cocktail, Code Y1443. Original diagnosis by Pap cytology.
Disclaimer: Due to variances among color computer monitors, the colors you see on your screen may not be the exact colors of the stain. The image you see should be considered close renditions to the actual stain.