GenPoint™ HPV Probe is an HPV probe cocktail that identifies the 13 most prevalent high-risk HPV genotypes, including types 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, and 68. GenPoint™ HPV Probe contains HPV genomic DNA in the form of double-stranded fragments of 500 base pairs or less (biotinylated and unlabeled), and multiple biotinylated oligonucleotides from 25 to 40 bases in length. The probe is provided in 1 mL of in situ hybridization solution.

GenPoint™ HPV Probe is optimized for amplified in situ hybridization using the GenPoint™ Tyramide Signal Amplification System, Code K0620, on histology and cytology specimens. The combination of this amplified ISH detection system and the GenPoint™ HPV Probe is the most powerful chromogenic ISH system available. The GenPoint™ System enables the sensitive detection of 1-2 copies of HPV DNA within the nucleus of an infected cell. This is demonstrated by a single punctate stain within the nucleus when observed under a bright field microscope. Episomal HPV DNA is represented by diffuse staining over the entire nucleus. The GenPoint™ assay is automated on the Dako Hybridizer and Autostainer Plus for optimal and reproducible performance.