TCRB FISH DNA Probe, Split Signal

The human T-cell receptor beta (TCRB) locus at chromosome 7 consists of 85 genes. These genes are devided into 67 variable (TCRBV) genes, 2 diversity (TCRBD) gene segments, 14 joining (TCRBJ) gene segments, and 2 constant (TCRBC) genes. The TCR locus spans a region of 620 kb on chromosome 7 band q34. Y5421 is a probe mix based on a combination of DNA and PNA technology, and contains two ready-to-use FISH DNA probes and unlabeled PNA blocking probes. The FISH DNA probes are a mixture of a Texas Red-labeled DNA probe (TCRB-Downstream) covering 320 kb telomeric to the TCRB breakpoint cluster region and a fluorescein-labeled DNA probe (TCRB-Upstream) covering 732 kb centromeric to the TCRB breakpoint cluster region.

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0.2 mL
Product No. Y542129

Schematic illustration of TCRB FISH DNA Probe hybridization regions.

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