The labeled probes come in hybridization solutions formulated for rapid hybridization and low background binding to tissues. Dako HPV probes are double-stranded DNAs labeled with biotin, and fragmented to 50-600 base pairs to promote efficient tissue hybridization.

Human papillomavirus (HPV) is accepted as the primary causative agent in the development of cervical cancer. While there have been approximately 100 HPV genomic types identified, most of these are not oncogenic and therefore do not lead to the development of cervical cancer. Those HPV genotypes that have been identified as types that contribute to the development of cervical cancer are categorized into intermediate and high risk HPV.