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Monoclonal Mouse Anti-Human
CD43
Clone DF-T1
CD43 is an integral membrane protein typically expressed at high levels on all leucocytes, except most resting B lymphocytes.
Antibodies to CD43 may be useful for the identification of low-grade B-cell lymphomas and myeloid disorders.
B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma (FFPE) stained with FLEX Anti-CD43, Code IR636/IS636.
B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma. The neoplastic cells show a moderate distinct staining reaction, and normal T cells show a strong distinct staining reaction.
Clinical application for IR636/IS636. For identification of low-grade B-cell lymphoma, peripheral T-cell lymphoma and myeloid disorders.
Disclaimer: Due to variances among color computer monitors, the colors you see on your screen may not be the exact colors of the stain. The image you see should be considered close renditions to the actual stain.
- Optimized staining performance of both high- and low-expression structures
- Crisp and clear staining with no background
- Optimal laboratory efficiency with ready-to-use antibodies on Dako Autostainer Plus
FLEX Monoclonal Mouse Anti-Human CD43, Clone DF-T1, Ready-to-Use (Dako Autostainer/Autostainer Plus), is intended for use in immunohistochemistry together with Dako Autostainer/Autostainer Plus instruments. Antibodies against CD43 may be useful for the identification of low-grade B-cell lymphomas, peripheral T-cell lymphomas and myeloid disorders (1). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
The antibody causes rapid and vigorous aggregation among normal leucocytes and among T and myeloid/monocytic cell lines (5).
Clone: DF-T1(4). Isotype: IgG1, kappa.
- Leong A, Cooper K, Leong F. Manual of diagnostic antibodies for immunohistology. London: Oxford University Press; 1999. p. 91-2.
- Stross WP, Warnke RA, Flavell DJ, Flavell SU, Simmons D, Gatter KC, et al. Molecule detected in formalin fixed tissue by antibodies MT1, DF-T1, and L60 (Leu-22) corresponds to CD43 antigen. J Clin Pathol 1989;42:953-61.
- de Smet W, Walter H, van Hove L. A new CD43 monoclonal antibody induces homotypic aggregation of human leucocytes through a CD11a/CD18-dependent and -independent mechanism. Immunology 1993;79:46-54.
| Product | Size |  | IS636 Clone DF-T1
| 30 tests, 6 mL Product No. IS63630 |
|---|
RECOMMENDED COMPANION PRODUCTS
| Step | Product | Size |
|---|---|---|
| Pre-treatment | EnVision™ FLEX Target Retrieval Solution, High pH (Code K8004) 3-in-1 procedure using PT Link | 3 x 30 mL Product No. K800421 |
| Antibody Dilution | Ready-to-use / Prediluted | |
| Negative Control | FLEX Negative Control, Mouse (Code IS750) Positive tissue: Tonsil | 60 tests, 12 mL Product No. IS75061 |
| Visualization System | EnVision™ FLEX (Code K8010) Use High pH Target Retrieval Solution | 400-600 tests Product No. K801021 |
| Counterstain | Hematoxylin (Dako Autostainer/Autostainer Plus) (Code K8018) Non-aqueous, permanent mounting medium is required | 10 x 13 mL, 400-600 tests Product No. K801821 |
| Glass Slides | FLEX IHC Microscope Slides (Code K8020) Recommended for greater adherence | 5 x 100 slides Product No. K802021 |