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Monoclonal Mouse Anti-Human
Beta-catenin is an 88 kDa multifunctional protein playing an essential role in cell-cell adhesion by binding to the transmembrane protein, cadherin.
Beta-catenin is also involved in the regulation of gene expression as a mediator of the Wnt signaling pathway. The expression and intracellular localization of beta-catenin is altered in many types of cancers. Besides the reactivity with human beta-catenin, the M3539 antibody cross-reacts with mouse beta-catenin.
Colon adenocarcinoma. Many of the neoplastic cells show a moderate to strong nuclear staining reaction, while the normal epithelial cells show a membranous staining reaction.
Clinical application for IR702/IS702. For identification of desmoid tumors, colorectal cancer and colon adenoma.
Disclaimer: Due to variances among color computer monitors, the colors you see on your screen may not be the exact colors of the stain. The image you see should be considered close renditions to the actual stain.
- Optimized staining performance of both high and low-expression structures
- Crisp and clear staining with no background
- Optimal laboratory efficiency with ready-to-use antibodies on Dako Autostainer Plus
|Product||Size||IS702 Clone β-Catenin-1||30 tests, 6 mL |
Packaged in vials for use with Dako Autostainer instruments
Product No. IS70230