Monoclonal Mouse Anti-Human

LAT Protein

Clone LAT-1

LAT (linker for activation of T cells) protein appears early in the T-cell development, at the thymocyte stage, and before expression of terminal deoxynucleotidyl transferase (TdT) in embryos. It is expressed by natural killer cells and T cells without restriction to any T-cell subpopulation. Megakaryocytes and mast cells also express LAT protein, whereas other myeloid cells, monocytic derived cells and B cells do not express LAT protein.

Isotype IgG1, kappa

  • Frozen
  • Formalin
  • HIER
+

Colon carcinoma (FFPE) stained with Anti-LAT Protein, Code M7279.

Disclaimer: Due to variances among color computer monitors, the colors you see on your screen may not be the exact colors of the stain. The image you see should be considered close renditions to the actual stain.

  • Excellent specificity
  • High lot to lot consistency
  • Optimized for immunohistochemistry (IHC) with validated protocols
  • Certified manufacturing facilities guarantee full quality control
Dako's products are the result of 40 years experience ensuring quality and innovation in antibodies and reagents: the genesis of the pathology lab of tomorrow.

Intended Use
For in vitro diagnostic use.

Monoclonal Mouse Anti-Human LAT Protein, Clone LAT-1, is intended for use in immunocytochemistry. The antibody label T cells, natural killer (NK) cells, megakaryocytes, and mast cells. Antibodies to LAT protein are useful for the identification of T-cell lymphoma subtypes (1). Differential identification is aided by the results from a panel of antibodies. Interpretation must be made within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
Immunogen
Recombinant protein corresponding to the cytoplasmic domain of human LAT protein.
Specificity
In Western blot analysis using protein extracts from a human T-cell leukaemia cell line (HSB-2), human platelets and human reactive lymph nodes, the antibody labels human LAT protein.

As demonstrated by immunocytochemistry on formalin-fixed, paraffin-embedded tissues, the antibody does not cross-react with the LAT-equivalent protein in cow, dog, horse, mouse, rat or swine.
Reagent Provided
Monoclonal mouse antibody provided in liquid form as cell culture supernatant dialysed against 0.05 mol/L Tris/HCl, pH 7.2, and containing 15 mmol/L NaN3.

Clone: LAT-1. Isotype: IgG1, kappa.

Mouse IgG concentration (mg/L): See label on vial.
References
  1. Facchetti F, Chan JKC, Zhang W, Tironi A, Chilosi M, Parolini S, et al. Technical Advance. Linker for activation of T cells (LAT), a novel immunohistochemical marker for T cells, NK cells, mast cells, and megakaryocytes. Am J Pathol 1999, 154:1037-46.
ProductSize
This product is CE-marked according to the EU IVD Directive 98/79/ECM7279 Culture supernatant
Specification Sheet
Safety Data Sheet:
Non-hazard classification statement
0.2 mL
Product No. M727929-2

Synonym(s) for Antigen

linker for activation of T cells

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