Denmark
c-Kit pharmDx™ Kits
c-kit, otherwise known as CD117 and stem cell factor receptor, is a 145 kDa type III transmembrane receptor tyrosine kinase encoded by the c-Kit proto-oncogene. Studies suggest that the c-Kit gene product is closely related to the process of malignant transformation, and to the pathogenesis of some specific types of human solid tumors (1-3).
References:
Gastrointestinal tumor (FFPE), stained with c-Kit pharmDx™, Code K1906 or K1907; 3+ staining.
References:
- de Silva CM, Reid R. Gastrointestinal stromal tumors (GIST): C-kit mutations, CD117 expression, differential diagnosis and targeted cancer therapy with Imatinib. Pathol Oncol Res 2003;9:13-9.
- van Oosterom AT, Judson I, Verweij J, Stroobants S, Donato di Paola E, Dimitrijevic S, et al. Safety and efficacy of imatinib (STI571) in metastatic gastrointestinal stromal tumours: a phase I study. Lancet 2001;358:1421-3.
- Miettinen M, Lasota J. Gastrointestinal stromal tumors - definition, clinical, histological, immunohistochemical, and molecular genetic features and differential diagnosis. Virchows Arch 2001;438:1-12.
Gastrointestinal tumor (FFPE), stained with c-Kit pharmDx™, Code K1906 or K1907; 3+ staining.