IGH FISH DNA Probe, Split Signal

The IGH locus at chromosome 14 consists of 170-176 genes. These genes are divided into 123-129 variable (IGHV) genes, 27 diversity (IGHD) gene segments, 9 joining (IGHJ) gene segments, and 11 constant (IGHC) genes. The IGH locus spans a region of 1.25 Mb on chromosome 14 band q32. Y5406 is a probe mix based on a combination of DNA and PNA technology, and contains two ready-to-use FISH DNA probes and unlabeled PNA blocking probes. The FISH DNA probes are a mixture of a Texas Red-labeled DNA probe (IGH-Downstream) covering 460 kb centromeric to the IGH breakpoint cluster region and a fluorescein-labeled DNA probe (IGH-Upstream) covering 612 kb telomeric to the IGH breakpoint cluster region.

IGH gene translocation. Courtesy of Euro-FISH.

Disclaimer: Due to variances among color computer monitors, the colors you see on your screen may not be the exact colors of the stain. The image you see should be considered close renditions to the actual stain.

ProductSDS (Safety Data Sheet)Size
For Research Use Only. Not for use in diagnostic proceduresY5406 Probe (containing Formamide)
20 tests, 0.2 mL
Product No. Y540629-8

Schematic illustration of IGH FISH DNA Probe hybridization regions.

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