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Monoclonal Mouse Anti-Human
CD2
Clone AB75
CD2 is a transmembrane glycoprotein that is considered a pan-T-cell antigen expressed on the majority of thymocytes and virtually all peripheral T lymphocytes.
Among neoplasms, the majority of precursor and post thymic lymphomas and leukemias show CD2 expression, while B-cell neoplasms usually do not. The antibody is especially useful for identification of peripheral T-cell lymphoma, anaplastic large cell lymphoma and precursor T-cell lymphoma.
Precursor T-lymphoblastic lymphoma (FFPE) stained with FLEX Anti-CD2, Code IR651/IS651.
Precursor T-lymphoblastic leukemia/lymphoma. The majority of the neoplastic cells show a distinct predominantly membranous staining reaction.
Clinical application for IR651/IS651. For identification of normal T cells and related neoplasms such as precursor T-lymphoblastic leukemia/lymphoma, peripheral T-cell lymphoma and anaplastic large cell lymphoma.
Disclaimer: Due to variances among color computer monitors, the colors you see on your screen may not be the exact colors of the stain. The image you see should be considered close renditions to the actual stain.
- Optimized staining performance of both high- and low-expression structures
- Crisp and clear staining with no background
- Optimal laboratory efficiency with ready-to-use antibodies on Dako Autostainer Link 48
FLEX Monoclonal Mouse Anti-Human CD2, Clone AB75, Ready-to-Use (Link), is intended for use in immunohistochemistry together with Autostainer Link instruments. This antibody labels normal T cells and related neoplasms and is especially useful for the identification of precursor T-cell lymphoma (1), peripheral T-cell lymphoma (2) and anaplastic large cell lymphoma (3). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
Clone: AB75. Isotype: IgG1, kappa.
- Hyjek E, Chadburn A, Liu YF, Cesarman E, Knowles DM. BCL-6 protein is expressed in precursor T-cell lymphoblastic lymphoma and in prenatal and postnatal thymus. Blood 2001;97:270-76.
- Went P, Agostinelli C, Gallaminni A, Piccaluga PP, Ascani S, Sabattini E, et al. Marker expression in peripheral T-cell lymphoma: A proposed clinical-pathological prognostic score. J Clin Oncol 2006;24:2472-79.
- D'Amore SEG, Menin A, Bonoldi E, Bevilacqua P, Cazzavilan S, Donofrio V, et al. Anaplastic large cell lymphomas: A study of 75 pediatric patients. Pediatr Dev Pathol 2007;10:181-91.
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| Product | Size |  | IR651 Clone AB75
| 60 tests, 12 mL Product No. IR65161-2 |
|---|
RECOMMENDED COMPANION PRODUCTS
| Step | Product | Size |
|---|---|---|
| Pre-treatment | EnVision™ FLEX Target Retrieval Solution, High pH (Code K8004) 3-in-1 procedure using PT Link | 3 x 30 mL Product No. K800421-2 |
| Antibody Dilution | Ready-to-use / Prediluted | |
| Negative Control | FLEX Negative Control, Mouse (Code IR750) Positive tissue: Tonsil | 120 tests, 24 mL Product No. IR75066-2 |
| Visualization System | EnVision™ FLEX+ (Code K8002) Use High pH Target Retrieval Solution | 400-600 tests Product No. K800221-2 |
| Counterstain | Hematoxylin (Link) (Code K8008) Non-aqueous, permanent mounting medium is required | 3 x 45 mL, 400-600 tests Product No. K800821-2 |
| Glass Slides | Silanized Slides (Code S3003) Recommended for greater adherence Alternative is FLEX IHC Microscope Slides (Code K8020) | 100 slides Product No. S300330-2 |