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Monoclonal Mouse Anti-Human
B-Cell-Specific Activator Protein
Clone DAK-Pax5
B-cell-specific activator protein, BSAP, also known as Pax-5, is a transcription factor expressed in B cells.
Antibodies to BSAP may be useful for the identification of pro, pre, and mature B cells and in the classification of lymphomas. Together with a panel of antibodies it is particularly useful in the differential identification of classic Hodgkin's disease versus anaplastic large cell lymphoma of the T and null-cell type.
B-cell chronic lymphatic leukemia (FFPE) stained with FLEX Anti-BSAP, Code IR650/IS650.
B-cell chronic lymphatic leukemia/small lymphocytic lymphoma. The majority of the neoplastic cells show a moderate to strong nuclear staining reaction.
Clinical application for IR650/IS650. For identification of pro/pre B cells, mature B cells and in the classification of lymphomas
Disclaimer: Due to variances among color computer monitors, the colors you see on your screen may not be the exact colors of the stain. The image you see should be considered close renditions to the actual stain.
- Optimized staining performance of both high- and low-expression structures
- Crisp and clear staining with no background
- Optimal laboratory efficiency with ready-to-use antibodies on Dako Autostainer Link 48
FLEX Monoclonal Mouse Anti-Human B-Cell-Specific Activator Protein, Clone DAK-Pax5, Ready-to-Use (Link), is intended for use in immunohistochemistry together with Autostainer Link instruments. Antibodies to B-cell-specific activator protein (BSAP) may be useful for the identification of pro-, pre-, and mature B cells and in the classification of lymphomas (1-4). Together with a panel of antibodies it is particularly useful in the differential identification of classic Hodgkin's disease versus anaplastic large cell lymphoma of T- and null-cell type (1, 3). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
Clone: DAK-Pax5. Isotype: IgG1, kappa.
- Browne P, Petrosyan K, Hernandez A, Chan JA. The B-cell transcription factors BSAP, Oct-2, and BOB.1 and the pan-B-cell markers CD20, CD22 and CD79a are useful in the differential diagnosis of classic Hodgkin lymphoma. Am J Clin Pathol 2003;120:767-77.
- Krenacs L, Himmelmann AW, Quintanilla-Martinez L, Fest T, Riva A, Wellmann A, et al. Transcription factor B-cell-specific activator protein (BSAP) is differentially expressed in B cells and in subsets of B-cell lymphomas. Blood 1998;92:1308-16.
- Torlakovic E, Torlakovic G, Nguyen PL, Brunning RD, Delabie J. The value of anti-pax-5 immunostaining in routinely fixed and paraffin-embedded sections: a novel pan pre-B and B-cell marker. Am J Surg Pathol 2002;26:1343-50.
- Zhang X, Lin Z, Kim I. Pax5 expression in non-Hodgkin's lymphomas and acute leukemias. J Korean Med Sci 2003;18:804-8.
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| Product | Size |  | IR650 Clone DAK-Pax5
| 60 tests, 12 mL Product No. IR65061-2 |
|---|
RECOMMENDED COMPANION PRODUCTS
| Step | Product | Size |
|---|---|---|
| Pre-treatment | EnVision™ FLEX Target Retrieval Solution, Low pH (Code K8005) 3-in-1 procedure using PT Link | 3 x 30 mL Product No. K800521-2 |
| Antibody Dilution | Ready-to-use / Prediluted | |
| Negative Control | FLEX Negative Control, Mouse (Code IR750) Positive tissue: Tonsil | 120 tests, 24 mL Product No. IR75066-2 |
| Visualization System | EnVision™ FLEX+ (Code K8002) Use Low pH Target Retrieval Solution | 400-600 tests Product No. K800221-2 |
| Counterstain | Hematoxylin (Link) (Code K8008) Non-aqueous, permanent mounting medium is required | 3 x 45 mL, 400-600 tests Product No. K800821-2 |
| Glass Slides | FLEX IHC Microscope Slides (Code K8020) Recommended for greater adherence | 5 x 100 slides Product No. K802021-2 |