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Monoclonal Mouse Anti-Human
Caldesmon
Clone h-CD
Caldesmon is a smooth muscle-specific protein involved in the regulation of smooth muscle contraction.
The antibody recognizes the high molecular mass variant of caldesmon (h-caldesmon) and does not react with the non-muscle variant.
Leiomyoma (FFPE) stained with FLEX Anti-Caldesmon, Code IR054/IS054.
Leiomyoma. The neoplastic cells and smooth muscle cells of small blood vessel wall show a strong cytoplasmic staining reaction.
Clinical application for IR054/IS054. For identification of smooth muscle and tumors with smooth muscle origin such as leiomyosarcoma, leiomyoma, angioleiomyoma and glomus tumor.
Disclaimer: Due to variances among color computer monitors, the colors you see on your screen may not be the exact colors of the stain. The image you see should be considered close renditions to the actual stain.
- Optimized staining performance of both high- and low-expression structures
- Crisp and clear staining with no background
- Optimal laboratory efficiency with ready-to-use antibodies on Dako Autostainer Plus
FLEX Monoclonal Mouse Anti-Human Caldesmon, Clone h-CD, Ready-to-Use (Dako Autostainer/Autostainer Plus), is intended for use in immunohistochemistry with Dako Autostainer/Autostainer Plus instruments. This antibody is useful for the identification of tumors with smooth muscle cell differentiation (1, 2). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
Clone: h-CD. Isotype: IgG1, kappa.
- Frid MG, et al. Phenotypic changes of human smooth muscle cells during development: Late expression of heavy caldesmon and calponin. Dev Biol 1992; 153:185
- Watanabe K, et al. h-Caldesmon in leiomyosarcoma and tumors with smooth muscle cell-like differentiation: its specific expression in the smooth muscle cell tumor, Hum Pathol 1999, 30:392-396
- Sobue K and Sellers JR. Caldesmon, a novel regulatory protein in smooth muscle and nonmuscle actomyosin systems. J Biol Chem 1991; 266(19):12115
Check Your Price & Order Online
| Product | Size |  | IS054 Clone h-CD
| 30 tests, 6 mL Product No. IS05430-2 |
|---|
RECOMMENDED COMPANION PRODUCTS
| Step | Product | Size |
|---|---|---|
| Pre-treatment | EnVision™ FLEX Target Retrieval Solution, High pH (Code K8004) 3-in-1 procedure using PT Link | 3 x 30 mL Product No. K800421-2 |
| Antibody Dilution | Ready-to-use / Prediluted | |
| Negative Control | FLEX Negative Control, Mouse (Code IS750) Positive tissue: Smooth muscle cells | 60 tests, 12 mL Product No. IS75061-2 |
| Visualization System | EnVision™ FLEX+ (Code K8012) Use High pH Target Retrieval Solution | 400-600 tests Product No. K801221-2 |
| Counterstain | Hematoxylin (Dako Autostainer/Autostainer Plus) (Code K8018) Non-aqueous, permanent mounting medium is required | 10 x 13 mL, 400-600 tests Product No. K801821-2 |
| Glass Slides | Silanized Slides (Code S3003) Recommended for greater adherence Alternative is FLEX IHC Microscope Slides (Code K8020) | 100 slides Product No. S300330-2 |