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Polyclonal Rabbit Anti-Human
Thyroglobulin
Thyroglobulin is the precursor of thyroid hormones.
It is synthesized by thyrocytes and transported to the apical surface where it is secreted into the lumen of thyroid follicles and stored as the major component of colloid. The antibody is useful for the detection of thyroglobulin in thyroid tissue and is a useful tool for the identification of well-differentiated thyroid carcinomas.
Thyroid follicular carcinoma (FFPE) stained with FLEX Anti-Thyroglobulin, Code IR509/IS509.
Thyroid follicular carcinoma. The neoplastic cells show a strong cytoplasmic staining reaction.
Clinical application for IR509/IS509 For identification of tumors of thyroid origin such as thyroid follicular carcinoma, papillary thyroid carcinoma, Hürthle cell tumor of thyroid, and anaplastic carcinoma of thyroid.
Disclaimer: Due to variances among color computer monitors, the colors you see on your screen may not be the exact colors of the stain. The image you see should be considered close renditions to the actual stain.
- Optimized staining performance of both high- and low-expression structures
- Crisp and clear staining with no background
- Optimal laboratory efficiency with ready-to-use antibodies on Dako Autostainer Link 48
FLEX Polyclonal Rabbit Anti-Human Thyroglobulin, Ready-to-Use (Link), is intended for use in immunohistochemistry together with Autostainer Link instruments. This antibody is useful for the identification of thyroglobulin in thyroid tissue and is a useful tool for the identification of well differentiated thyroid carcinomas (1, 2). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
In crossed immunoelectrophoresis using 12.5 µL concentrated antibody per cm2 gel area against 2 µL of human thyroid gland extract, only one precipitate corresponding to Tg appears. With 2 µL of human plasma, no precipitate appears. Staining: Coomassie Brilliant Blue.
In human thyroid cell cultures, the antibody labels intracellular Tg (4).
- Albores-Saavedra J, Nadji M, Civantos F, Morales AR. Thyroglobulin in carcinoma of the thyroid: An immunohistochemical study. Hum Pathol 1983;14:62-6.
- Burt AD, Kerr DJ, Brown IL, Boyle P. Lymphoid and epithelial markers in small cell anaplastic thyroid tumors. J Clin Pathol 1985;38:893-6.
- Kayser L, Olsen BE, Høyer PE. Quantitative cytochemical demonstration of intracellular thyroglobulin in cultured human thyrocytes. Effects of fixatives, TSH and interleukin-1a. Histochem J 1991;23:235-40
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| Product | Size |  | IR509
| 60 tests, 12 mL Product No. IR50961-2 |
|---|
RECOMMENDED COMPANION PRODUCTS
| Step | Product | Size |
|---|---|---|
| Pre-treatment | EnVision™ FLEX Target Retrieval Solution, High pH (Code K8004) 3-in-1 procedure using PT Link | 3 x 30 mL Product No. K800421-2 |
| Antibody Dilution | Ready-to-use / Prediluted | |
| Negative Control | FLEX Negative Control, Rabbit (Code IR600) Positive tissue: Thyroid | 120 tests, 24 mL Product No. IR60066-2 |
| Visualization System | EnVision™ FLEX (Code K8000) Use High pH Target Retrieval Solution | 400-600 tests Product No. K800021-2 |
| Counterstain | Hematoxylin (Link) (Code K8008) Non-aqueous, permanent mounting medium is required | 3 x 45 mL, 400-600 tests Product No. K800821-2 |
| Glass Slides | FLEX IHC Microscope Slides (Code K8020) Recommended for greater adherence | 5 x 100 slides Product No. K802021-2 |