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Monoclonal Mouse Anti-Human
CD8
Clone C8/144B
CD8 is a 68 kDa transmembrane glycoprotein expressed as a heterodimer by a majority of thymocytes, and by class I major histocompatibility complex restricted, mature, suppressor/cytotoxic T cells.
The antibody is useful for the identification of cytotoxic/suppressor T cells and their neoplastic counterparts.
Peripheral T-cell lymphoma (FFPE) stained with FLEX Anti-CD8, Code IR623/IS623.
Peripheral T-cell lymphoma. Focally, the neoplastic cells show a moderate to strong cytoplasmic and membraneous staining reaction.
Clinical application for IR623/IS623. For identification of cytotoxic/suppressor T cells and their neoplastic counterparts.
Disclaimer: Due to variances among color computer monitors, the colors you see on your screen may not be the exact colors of the stain. The image you see should be considered close renditions to the actual stain.
- Optimized staining performance of both high- and low-expression structures
- Crisp and clear staining with no background
- Optimal laboratory efficiency with ready-to-use antibodies on Dako Autostainer Link 48
FLEX Monoclonal Mouse Anti-Human CD8, Clone C8/144B, Ready-to-Use (Link), is intended for use in immunohistochemistry together with Autostainer Link instruments. This antibody labels cytotoxic/supressor T cells and is useful for the identification of these cells and their neoplastic counterparts (1). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
Clone: C8/144B (1). Isotype: IgG1, kappa.
- Mason DY, Cordell JL, Gaulard P, Tse AGD, Brown MH. Immunohistological detection of human cytotoxic/suppressor T cells using antibodies to a CD8 peptide sequence. J Clin Pathol 1992:45:1084-8.
| Product | Size |  | IR623 Clone C8/144B
| 60 tests, 12 mL Product No. IR62361 |
|---|
RECOMMENDED COMPANION PRODUCTS
| Step | Product | Size |
|---|---|---|
| Pre-treatment | EnVision™ FLEX Target Retrieval Solution, High pH (Code K8004) 3-in-1 procedure using PT Link | 3 x 30 mL Product No. K800421 |
| Antibody Dilution | Ready-to-use / Prediluted | |
| Negative Control | FLEX Negative Control, Mouse (Code IR750) Positive tissue: Tonsil | 120 tests, 24 mL Product No. IR75066 |
| Visualization System | EnVision™ FLEX (Code K8000) Use High pH Target Retrieval Solution | 400-600 tests Product No. K800021 |
| Counterstain | Hematoxylin (Link) (Code K8008) Non-aqueous, permanent mounting medium is required | 3 x 45 mL, 400-600 tests Product No. K800821 |
| Glass Slides | FLEX IHC Microscope Slides (Code K8020) Recommended for greater adherence | 5 x 100 slides Product No. K802021 |