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Monoclonal Mouse Anti-Human
CD19
Clone LE-CD19
CD19 is the broadest lineage-specific surface marker for B cells.
CD19 is present on the surface of virtually all B lymphocytes, including early B-progenitor cells, but it is lost upon terminal differentiation to plasma cells. CD19 is also expressed on follicular dendritic cells (1). B-lineage leukemias and lymphomas rarely lose the CD19 antigen (2).
- Sato S, Tedder TF. BC3. CD19 workshop panel report. In: Kishimoto T, Kikutani H, von dem Borne AEG, Goyert SM, Mason DY, Miyasaka M, et al., editors. Leucocyte typing VI. White cell differentiation antigens. Proceedings of the 6th International Workshop and Conference; 1996 Nov 10-14; Kobe, Japan. New York, London: Garland Publishing Inc.; 1997. p. 133-5.
- Scheuermann RH, Racila E. CD19 antigen in leukaemia and lymphoma diagnosis and immunotherapy (review). Leuk Lymphoma 1995;18:385-97.
B-cell chronic lymphatic leukemia (FFPE) stained with FLEX Anti-CD19, Code IR656/IS656.
B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma. The majority of the neoplastic cells show a moderate to strong predominantly membranous staining reaction.
Clinical application for IR656/IS656. For identification of B cells in normal and neoplastic tissue.
Disclaimer: Due to variances among color computer monitors, the colors you see on your screen may not be the exact colors of the stain. The image you see should be considered close renditions to the actual stain.
- Optimized staining performance of both high- and low-expression structures
- Crisp and clear staining with no background
- Optimal laboratory efficiency with ready-to-use antibodies on Dako Autostainer Link 48
FLEX Monoclonal Mouse Anti-Human CD19, Clone LE-CD19, Ready-to-Use (Link), is intended for use in immunohistochemistry together with Autostainer Link instruments. This antibody labels B cells in normal and neoplastic tissue. The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
Clone: LE-CD19. Isotype: IgG1, kappa.
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| Product | Size |  | IR656 Clone LE-CD19
| 60 tests, 12 mL Product No. IR65661-2 |
|---|
RECOMMENDED COMPANION PRODUCTS
| Step | Product | Size |
|---|---|---|
| Pre-treatment | EnVision™ FLEX Target Retrieval Solution, High pH (Code K8004) 3-in-1 procedure using PT Link | 3 x 30 mL Product No. K800421 |
| Antibody Dilution | Ready-to-use / Prediluted | |
| Negative Control | FLEX Negative Control, Mouse (Code IR750) Positive tissue: Tonsil and colon | 120 tests, 24 mL Product No. IR75066-2 |
| Visualization System | EnVision™ FLEX (Code K8000) Use High pH Target Retrieval Solution | 400-600 tests Product No. K800021 |
| Counterstain | Hematoxylin (Link) (Code K8008) Non-aqueous, permanent mounting medium is required | 3 x 45 mL, 400-600 tests Product No. K800821 |
| Glass Slides | FLEX IHC Microscope Slides (Code K8020) Recommended for greater adherence | 5 x 100 slides Product No. K802021-2 |