Dako has successfully introduced the peptide nucleic acid (PNA) probe, a nucleotide analogue capable of binding to DNA/RNA in a sequence-specific manner. This increases the affinity of our probes - thereby enhancing the visualization. Furthermore, the PNA's are very stable - no degradation by DNases, RNases, proteinases or peptidases have been observed in clinical experiments, leaving you with the optimal test results.
Dako has developed kits and reagents for both ISH, FISH and CISH applications, and both our HER2 FISH and TOP2A pharmDx kits are FDA-approved. The PNA technology is implemented in our FISH DNA probes and FISH Probe Mix.
Hybridizer is a hands-free denaturation and hybridization instrument designed for slide-based fluorescence and chromogenic in situ hybridization (FISH and CISH, respectively) on histology and cytology samples.
The instrument allows for semi-automation of ISH by eliminating steps in the time-intensive manual procedure and can be integrated in laboratories working with Dako Autostainer Plus and other Dako systems.