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Polyclonal Rabbit Anti-Human
Calcitonin
Calcitonin is a 32 amino acid peptide hormone, produced in the parafollicular C cells of the thyroid.
Calcitonin acts through its receptors, causing osteoclast-mediated bone resorption and calcium excretion by the kidney. The antibody is useful for the identification of calcitonin-producing C cells, from which medullary thyroid carcinoma originates.
Thyroid medullary carcinoma (FFPE) stained with FLEX Anti-Calcitonin, Code IR515/IS515.
Thyroid medullary carcinoma. The neoplastic cells show a strong staining reaction for calcitonin.
Clinical application for IR515/IS515. For identification of thyroid medullary carcinoma and thyroid C cells.
Disclaimer: Due to variances among color computer monitors, the colors you see on your screen may not be the exact colors of the stain. The image you see should be considered close renditions to the actual stain.
- Optimized staining performance of both high- and low-expression structures
- Crisp and clear staining with no background
- Optimal laboratory efficiency with ready-to-use antibodies on Dako Autostainer Plus
FLEX Polyclonal Rabbit Anti-Human Calcitonin, Ready-to-Use (Dako Autostainer/Autostainer Plus), is intended for use in immunohistochemistry together with Dako Autostainer/Autostainer Plus instruments. This antibody is useful for the identification of calcitonin-producing C-cells, from which medullary thyroid carcinoma (MTC) originates (1). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
The antibody labels human thyroid C-cells, and other calcitonin-containing cells strongly and specifically. No non-specific staining has been observed.
- Hayashida CY, Alves VAF, Kanamura CT, Ezabella CL, Abelin NM, Nicolau W, et al. Immunohisto-chemistry of medullary thyroid carcinoma and C-cell hyperplasia by an affinity-purified anti-human calcitonin antiserum. Cancer 1993;72:1356-63.
| Product | Size |  | IS515
| 30 tests, 6 mL Product No. IS51530 |
|---|
RECOMMENDED COMPANION PRODUCTS
| Step | Product | Size |
|---|---|---|
| Pre-treatment | EnVision™ FLEX Target Retrieval Solution, High pH (Code K8004) 3-in-1 procedure using PT Link | 3 x 30 mL Product No. K800421 |
| Antibody Dilution | Ready-to-use / Prediluted | |
| Negative Control | FLEX Negative Control, Rabbit (Code IS600) Positive tissue: Thyroid | 60 tests, 12 mL Product No. IS60061 |
| Visualization System | EnVision™ FLEX (Code K8010) Use High pH Target Retrieval Solution | 400-600 tests Product No. K801021 |
| Counterstain | Hematoxylin (Dako Autostainer/Autostainer Plus) (Code K8018) Non-aqueous, permanent mounting medium is required | 10 x 13 mL, 400-600 tests Product No. K801821 |
| Glass Slides | FLEX IHC Microscope Slides (Code K8020) Recommended for greater adherence | 5 x 100 slides Product No. K802021 |