Luxemburg
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Monoclonal Mouse Anti-Human
CD79α
Clone JCB117
CD79α is encoded by the mb-1 gene and was previously called Igα.
The antibody recognizes an extracellular epitope expressed on the CD79α molecule, and detects the full spectrum of B-cell neoplasms in routine biopsy material. In addition to the expression in B cells, CD79α has been found to be co-expressed with CD3 in 10% of cases of T-lymphoblastic leukemia/lymphoma. Antibodies to CD79α may also be useful in the differential diagnosis of Hodgkin's disease.
The antibody is well-suited for use on cell smears and tissue sections, but not for flow cytometry.
- Mason DY, Cordell JL, Brown MH, Borst J, Jones M, Pulford K, et al. CD79a: a novel marker for B-cell neoplasms in routinely processed tissue samples. Blood 1995;86:1453-9.
- Pilozzi E, Pulford K, Jones M, Muller-Hermelink HK, Falini B, Ralfkiaer E, et al. Co-expression of CD79a (JCB117) and CD3 by lymphoblastic lymphoma. J Pathol 1998;186:140-3.
- Chu PG, Arber DA. CD79: a review. Appl Immunohistochem Mol Morphol 2001;9:97-106
Precursor B-lymphoblastic leukemia/lymphoma (FFPE) stained with FLEX Anti-CD79α, Code IR621/IS621.
Precursor B-lymphoblastic leukemia/lymphoma disseminated to the testis. The majority of the neoplastic cells show a weak to moderate staining reaction
Clinical application for IR621/IS621. For identification of B cells during all stages of differentiation and of B-cell neoplasm.
Disclaimer: Due to variances among color computer monitors, the colors you see on your screen may not be the exact colors of the stain. The image you see should be considered close renditions to the actual stain.
- Optimized staining performance of both high- and low-expression structures
- Crisp and clear staining with no background
- Optimal laboratory efficiency with ready-to-use antibodies on Dako Autostainer Plus
FLEX Monoclonal Mouse Anti-Human CD79α, Clone JCB117, Ready-to-Use (Dako Autostainer/Autostainer Plus), is intended for use in immunohistochemistry together with Dako Autostainer/Autostainer Plus instruments. This antibody labels B cells and is useful for the identification of B-cell neoplasms of all maturation stages (1). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
In Western blotting of Ramos B-cell lysate, the antibody labels a band corresponding to CD79α under reducing conditions, and a band corresponding to CD79αβ under non-reducing conditions (1).
SDS-PAGE analysis of immunoprecipitates formed between the antibody and 125I-labeled, mildly denatured, and reduced lysate of Ramos B cells, shows weak reaction with a 43 kDa polypeptide corresponding to CD79α.
Clone: JCB117 (1). Isotype: IgG1, kappa.
- Mason DY, Cordell JL, Brown MH, Borst J, Jones M, Pulford K, et al. CD79a: a novel marker for B-cell neoplasms in routinely processed tissue samples. Blood 1995;86:1453-9.
- 4. Nakamura T. BC20. CD79 workshop panel report. In: Kishimoto T, Kikutani H, von dem Borne AEG, Goyert SM, Mason DY, Miyasaka M, et al., editors. Leucocyte typing VI. White cell differentiation antigens. Proceedings of the 6th International Workshop and Conference; 1996 Nov 10-14; Kobe, Japan. New York, London: Garland Publishing Inc.; 1997. p. 180-2.
| Product | Size |  | IS621 Clone JCB117
| 30 tests, 6 mL Product No. IS62130 |
|---|
RECOMMENDED COMPANION PRODUCTS
| Step | Product | Size |
|---|---|---|
| Pre-treatment | EnVision™ FLEX Target Retrieval Solution, High pH (Code K8004) 3-in-1 procedure using PT Link | 3 x 30 mL Product No. K800421 |
| Antibody Dilution | Ready-to-use / Prediluted | |
| Negative Control | FLEX Negative Control, Mouse (Code IS750) Positive tissue: Tonsil | 60 tests, 12 mL Product No. IS75061 |
| Visualization System | EnVision™ FLEX (Code K8010) Use High pH Target Retrieval Solution | 400-600 tests Product No. K801021 |
| Counterstain | Hematoxylin (Dako Autostainer/Autostainer Plus) (Code K8018) Non-aqueous, permanent mounting medium is required | 10 x 13 mL, 400-600 tests Product No. K801821 |
| Glass Slides | FLEX IHC Microscope Slides (Code K8020) Recommended for greater adherence | 5 x 100 slides Product No. K802021 |
Synonym(s) for Antigen
Ig-a, mb-1