In cancer diagnostics, the first step is H&E also called primary staining. H&E staining determine if cells in tissue look cancerous. If cells look abnormal, a differential diagnosis is required to determine the type of cancer. This is achieved with immunohistochemistry (IHC) and is known as secondary staining.
Immonuhistochemistry (IHC) takes its name from the roots “immuno,” in reference to antibodies used in the process, and “histo” meaning tissue, with “chemistry” referring to the technique used to perform the test. IHC is the localization of antigens, or proteins in tissue sections, through antigen-antibody interactions. These interactions are in turn visualized by a marker such as chromogens, fluorescent dye, or colloidal gold.
Recent breakthroughs in science have provided a greater understanding of many diseases, especially cancer. These breakthroughs have allowed the development of targeted therapies to treat complex diseases. However, to exploit these targeted therapies effectively, it is necessary to identify those patients who are most likely to respond to a particular treatment. This essential step is the science of companion diagnostics also called pharmacodiagnostic. By allowing doctors to find the right treatment to the right patient at the right time, companion diagnostics can be thought of as providing personalized medicine.
Molecular Pathology aids in deciphering the invisible features of cancer at a molecular level in order to provide precise diagnosis.
In cancer diagnostics, the first step is H&E also called primary staining. H&E staining determine if cells in tissue look cancerous.
Special Stains are special dyes or stains that are able to bind to specific tissues elements.
Dako's extensive range of antibody and isotype reagents for flow cytometry counts more than 220 products of which more than 200 are CE-IVD labeled. Our single-color, dual-color and triple-color reagents are applicable to major flow cytometry instruments and are the carefully selected combinations of antibodies and fluorochromes. Our antibody/fluorochrome range includes FITC, RPE, APC, RPE-Cy-5, Pacific Blue, and Cascade Yellow, as well as our newly launched PerCP and PerCP-Cy5.5 reagents. Using these reagents to evaluate the expression patterns of specific cellular markers can provide valuable adjunctive information about specific cell lineages and help classify hematologic malignancies.
Within the field of clinical immunochemistry, Dako has a long experience in producing reagents for the measurement of proteins in body fluids. These reagents have been developed particularly for turbidimetry, nephelometry and ELISA. These techniques exploit the fast, specific reaction between antibody and antigen. Apart from our comprehensive menu for turbidimetry the Specific Proteins portfolio also includes a range of our high quality polyclonal antibodies.