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Monoclonal Mouse Anti-Human
Progesterone Receptor
Clone PgR 636
Progesterone receptor (PR) is a steroid hormone receptor that plays an important role in breast cancer. The absence of PR and estrogen receptor (ER) predicts early recurrence and poor survival of breast cancer patients.
The antibody to PR is useful for measuring the relative level of expression of progesterone receptor in breast cancer tissue. This antibody is indicated for use as an aid in the management, prognosis and prediction of outcome of breast cancer.
Isotype IgG1, kappa
- Formalin
- HIER
Breast ductal carcinoma (FFPE) stained with FLEX Anti-Progesterone Receptor.
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Breast ductal carcinoma. The neoplastic cells show a strong nuclear staining reaction
Clinical application. For measuring of the relative level of expression for progesterone receptor in breast cancer tissue. It also labels meningioma cells.
Meningioma. Most neoplastic cells show a distinct nuclear staining reaction.
Clinical application. For measuring of the relative level of expression for progesterone receptor in breast cancer tissue. It also labels meningioma cells.
Uterine cervix. Epithelial cells and stromal cells show a strong staining reaction.
Recommended control. Cervix/Breast.
Breast. Ductal epithelial cells show a moderate to strong nuclear staining reaction. Some cytoplasmic staining is acceptable.
Recommended control. Cervix/Breast.
Breast carcinoma stained with Anti-Progesterone Receptor, Code M3569.
Disclaimer: Due to variances among color computer monitors, the colors you see on your screen may not be the exact colors of the stain. The image you see should be considered close renditions to the actual stain.
- Concentrated Antibody
for Manual Use - Ready-to-use Antibody
for Autostainer Link Instrument - Ready-to-use Antibody
for Autostainer Plus Instrument
- Excellent specificity
- High lot to lot consistency
- Optimized for immunohistochemistry (IHC) with validated protocols
- Certified manufacturing facilities guarantee full quality control
Intended Use
For in vitro diagnostic use.
Monoclonal Mouse Anti-Human Progesterone Receptor, clone PgR 636 is intended for laboratory use for the semi-quantitative detection of progesterone receptor by light microscopy in normal and pathological human paraffin-embedded tissue processed in neutral buffered formalin. This antibody is indicated for use as an aid in the management, prognosis and prediction of outcome of breast cancer. Positive results aid in the classification of normal and abnormal cells/tissues and serve as an adjunct to conventional histopathology. The clinical interpretation of any positive staining or its absence should be complemented by morphological and histological studies with proper controls. Evaluations should be made within the context of the patient's clinical history and other diagnostic tests by a qualified individual.
Monoclonal Mouse Anti-Human Progesterone Receptor, clone PgR 636 is intended for laboratory use for the semi-quantitative detection of progesterone receptor by light microscopy in normal and pathological human paraffin-embedded tissue processed in neutral buffered formalin. This antibody is indicated for use as an aid in the management, prognosis and prediction of outcome of breast cancer. Positive results aid in the classification of normal and abnormal cells/tissues and serve as an adjunct to conventional histopathology. The clinical interpretation of any positive staining or its absence should be complemented by morphological and histological studies with proper controls. Evaluations should be made within the context of the patient's clinical history and other diagnostic tests by a qualified individual.
Immunogen
Formalin-fixed recombinant full-length A-form of human progesterone receptor (1).
Specificity
Anti-PR, PgR 636 has been demonstrated to react with the PR-A and PR-B forms by Western blot of whole cell extracts and reacts with both free and hormone-bound PR (1). The epitope has been mapped to the amino terminal domain shared by PR-A and PR-B.
Reagent Provided
Monoclonal mouse antibody provided in liquid form as tissue culture supernatant in 0.05 mol/L Tris-HCl, pH 7.2 and 0.015 mol/L sodium azide. This product contains stabilizing protein.
Clone: PgR 636 (1). Isotype: IgG1, kappa.
Mouse lgG concentration mg/L: See label on vial.
The protein concentration between lots may vary without influencing the optimal dilution. The titer of each individual lot is compared and adjusted to a reference lot to ensure a consistent immunohistochemical staining performance from lot-to-lot.
Clone: PgR 636 (1). Isotype: IgG1, kappa.
Mouse lgG concentration mg/L: See label on vial.
The protein concentration between lots may vary without influencing the optimal dilution. The titer of each individual lot is compared and adjusted to a reference lot to ensure a consistent immunohistochemical staining performance from lot-to-lot.
References
- Press M, Spaulding B, Groshen S, Kaminsky D, Hagerty M, Sherman L, Christensen K, Edwards DP. Comparison of different antibodies for detection of progesterone receptor in breast cancer. Steroids 2002;67:799-813.
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| Product | Size |  | M3569 Culture supernatant
| 0.2 mL Product No. M356929-2 |
|---|---|---|
| 1 mL Product No. M356901-2 |
- Optimized staining performance of both high- and low-expression structures
- Crisp and clear staining with no background
- Optimal laboratory efficiency with ready-to-use antibodies on Dako Autostainer Link 48
Intended Use
For in vitro diagnostic use.
FLEX Monoclonal Mouse Anti-Human Progesterone Receptor, Clone PgR 636, Ready-to-Use (Link), is intended for use in immunohistochemistry together with Autostainer Link instruments. This antibody is useful for measuring the relative level of expression for progesterone receptor in breast cancer tissue. This antibody is indicated for use as an aid in the management, prognosis and prediction of outcome of breast cancer. The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
FLEX Monoclonal Mouse Anti-Human Progesterone Receptor, Clone PgR 636, Ready-to-Use (Link), is intended for use in immunohistochemistry together with Autostainer Link instruments. This antibody is useful for measuring the relative level of expression for progesterone receptor in breast cancer tissue. This antibody is indicated for use as an aid in the management, prognosis and prediction of outcome of breast cancer. The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
Immunogen
Formalin-fixed recombinant full-length A-form of human progesterone receptor (1).
Specificity
Anti-PR, PgR 636 has been demonstrated to react with the PR-A and PR-B forms by Western blot of whole cell extracts and reacts with both free and hormone-bound PR (1). The epitope has been mapped to the amino terminal domain shared by PR-A and PR-B.
Reagent Provided
Ready-to-use monoclonal mouse antibody provided in liquid form in a buffer containing stabilizing protein and 0.015 mol/L NaN3.
Clone: PgR 636 (1). Isotype: IgG1, kappa.
Clone: PgR 636 (1). Isotype: IgG1, kappa.
References
- Press M, Spaulding B, Groshen S, Kaminsky D, Hagerty M, Sherman L, Christensen K, Edwards DP. Comparison of different antibodies for detection of progesterone receptor in breast cancer. Steroids 2002;67:799-813.
Check Your Price & Order Online
| Product | Size | | IR068 RTU, FLEX
| 60 tests, 12 mL Product No. IR06861-2 |
|---|
RECOMMENDED COMPANION PRODUCTS
| Step | Product | Size |
|---|---|---|
| Pre-treatment | EnVision™ FLEX Target Retrieval Solution, High pH (Code K8004) 3-in-1 procedure using PT Link | 3 x 30 mL Product No. K800421-2 |
| Antibody Dilution | Ready-to-use / Prediluted | |
| Negative Control | FLEX Negative Control, Mouse (Code IR750) Positive tissue: Cervix and breast tissue | 120 tests, 24 mL Product No. IR75066-2 |
| Visualization System | EnVision™ FLEX+ (Code K8002) Use High pH Target Retrieval Solution | 400-600 tests Product No. K800221-2 |
| Counterstain | Hematoxylin (Link) (Code K8008) Non-aqueous, permanent mounting medium is required | 3 x 45 mL, 400-600 tests Product No. K800821-2 |
| Glass Slides | Silanized Slides (Code S3003) Recommended for greater adherence Alternative: FLEX IHC Microscope Slides (Code K8020) | 100 slides Product No. S300330-2 |
- Optimized staining performance of both high- and low-expression structures
- Crisp and clear staining with no background
- Optimal laboratory efficiency with ready-to-use antibodies on Dako Autostainer Plus
Intended Use
For in vitro diagnostic use.
FLEX Monoclonal Mouse Anti-Human Progesterone Receptor, Clone PgR 636, Ready-to-Use (Dako Autostainer/Autostainer Plus), is intended for use in immunohistochemistry together with Dako Autostainer/Autostainer Plus instruments. This antibody is useful for measuring the relative level of expression for progesterone receptor in breast cancer tissue. This antibody is indicated for use as an aid in the management, prognosis and prediction of outcome of breast cancer. The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
FLEX Monoclonal Mouse Anti-Human Progesterone Receptor, Clone PgR 636, Ready-to-Use (Dako Autostainer/Autostainer Plus), is intended for use in immunohistochemistry together with Dako Autostainer/Autostainer Plus instruments. This antibody is useful for measuring the relative level of expression for progesterone receptor in breast cancer tissue. This antibody is indicated for use as an aid in the management, prognosis and prediction of outcome of breast cancer. The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
Immunogen
Formalin-fixed recombinant full-length A-form of human progesterone receptor (1).
Specificity
Anti-PR, PgR 636 has been demonstrated to react with the PR-A and PR-B forms by Western blot of whole cell extracts and reacts with both free and hormone-bound PR (1). The epitope has been mapped to the amino terminal domain shared by PR-A and PR-B.
Reagent Provided
Ready-to-use monoclonal mouse antibody provided in liquid form in a buffer containing stabilizing protein and 0.015 mol/L NaN3.
Clone: PgR 636 (1). Isotype: IgG1, kappa.
Clone: PgR 636 (1). Isotype: IgG1, kappa.
References
- Press M, Spaulding B, Groshen S, Kaminsky D, Hagerty M, Sherman L, Christensen K, Edwards DP. Comparison of different antibodies for detection of progesterone receptor in breast cancer.
Steroids 2002;67:799-813.
Check Your Price & Order Online
| Product | Size | | IS068 RTU, FLEX
| 30 tests, 6 mL Product No. IS06830-2 |
|---|
RECOMMENDED COMPANION PRODUCTS
| Step | Product | Size |
|---|---|---|
| Pre-treatment | EnVision™ FLEX Target Retrieval Solution, High pH (Code K8004) 3-in-1 procedure using PT Link | 3 x 30 mL Product No. K800421-2 |
| Antibody Dilution | Ready-to-use / Prediluted | |
| Negative Control | FLEX Negative Control, Mouse (Code IS750) Positive tissue: Cervix and breast tissue | 60 tests, 12 mL Product No. IS75061-2 |
| Visualization System | EnVision™ FLEX+ (Code K8012) Use High pH Target Retrieval Solution | 400-600 tests Product No. K801221-2 |
| Counterstain | Hematoxylin (Dako Autostainer/Autostainer Plus) (Code K8018) Non-aqueous, permanent mounting medium is required | 10 x 13 mL, 400-600 tests Product No. K801821-2 |
| Glass Slides | Silanized Slides (Code S3003) Recommended for greater adherence Alternative: FLEX IHC Microscope Slides (Code K8020) | 100 slides Product No. S300330-2 |
Synonym(s) for Antigen
PR, PgR636