Labeled Probes and Detection Systems
In PNA, the sugar phosphate backbone of DNA/RNA has been replaced by a synthetic peptide backbone keeping the distances between bases exactly the same as in DNA/RNA. The increase in affinity is evident from the increase in the Tm of 1-1.5 °C per base pair. Further, the PNAs are very stable molecules. Experiments have shown virtually no degradation by DNases, RNases, proteinases or peptidases.
In this section, you will find Dako's molecular pathology products which are not intended for FISH. The probes are either visualized using the GenPoint CSA System, In Situ Hybridization Detection System, PNA ISH Dectection System or Chemiluminescent System for Nucleic Acid Blotting.
Human condyloma stained with a HPV Type 11, DNA probe.