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Monoclonal Mouse Anti-Human
Neuron-Specific Enolase (NSE)
Clone BBS/NC/VI-H14
Neuron-specific enolase is one of three main groups of enolases, the other two being non-neuronal enolase and muscle-specific enolase.
The antibody labels both normal and neoplastic cells of neuronal and neuroendocrine origin. Although neuron-specific enolase is not an exclusive neuronal marker, it may be used for the identification of peripheral nerves, neural and neuroendocrine tumors, such as neuroblastomas, retinoblastomas, desmoplastic malignant melanoma, and small-cell lung cancer.
Schwannoma (FFPE) stained with FLEX Anti-Neuron-Specific Enolase, Code IR612/IS612.
Schwannoma. The neoplastic cells show a weak to moderate staining reaction.
Clinical application for IR612/IS612 For identification of both normal neuronal and neuroendocrine cells and corresponding tumors such as schwannoma and carcinoid tumors.
Disclaimer: Due to variances among color computer monitors, the colors you see on your screen may not be the exact colors of the stain. The image you see should be considered close renditions to the actual stain.
- Optimized staining performance of both high- and low-expression structures
- Crisp and clear staining with no background
- Optimal laboratory efficiency with ready-to-use antibodies on Dako Autostainer Plus
FLEX Monoclonal Mouse Anti-Human Neuron-Specific Enolase, Clone BBS/NC/VI-H14, Ready-to-Use (Dako Autostainer/Autostainer Plus), is intended for use in immunohistochemistry together with Dako Autostainer/Autostainer Plus instruments. This antibody labels both normal and neoplastic cells of neuronal and neuroendocrine origin (1), and although neuron-specific enolase (NSE) is not an exclusive neuronal marker, it may be used for the identification of peripheral nerves, neural and neuroendocrine tumors, such as neuroblastomas, retinoblastomas, desmoplastic malignant melanoma and small-cell lung cancer (2, 3). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
As demonstrated by immunohistochemistry on formalin-fixed, paraffin-embedded tissue sections, the antibody cross-reacts with the NSE-equivalent protein in pig (1).
Clone: BBS/NC/VI-H14 (1). Isotype: IgG1, kappa.
- Soler Federsppiel BS, Cras P, Gheuens J, Andries D, Lowenthal A. Human ((-enolase: two-site immuno-radiometric assay with a single monoclonal antibody. J Neurochem 1987;48:22-8.
- Anstey A, Cerio R, Ramnarain N, Orchard G, Smith N, Jones EW. Desmoplastic malignant melanoma. An immunocytochemical study of 25 cases. Am J Dermatopathol 1994;16:14-22.
- Kang J-L, Meyts ER, Skakkebæk NE. Immunoreactive neuron-specific enolase (NSE) is expressed in testicular carcinoma-in-situ. J Pathol 1996;178:161-5.
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| Product | Size |  | IS612 Clone BBS/NC/VI-H14
| 30 tests, 6 mL Product No. IS61230-2 |
|---|
RECOMMENDED COMPANION PRODUCTS
| Step | Product | Size |
|---|---|---|
| Pre-treatment | EnVision™ FLEX Target Retrieval Solution, High pH (Code K8004) 3-in-1 procedure using PT Link | 3 x 30 mL Product No. K800421 |
| Antibody Dilution | Ready-to-use / Prediluted | |
| Negative Control | FLEX Negative Control, Mouse (Code IS750) Positive tissue: Colon | 60 tests, 12 mL Product No. IS75061-2 |
| Visualization System | EnVision™ FLEX (Code K8010) Use High pH Target Retrieval Solution | 400-600 tests Product No. K801021 |
| Counterstain | Hematoxylin (Dako Autostainer/Autostainer Plus) (Code K8018) Non-aqueous, permanent mounting medium is required | 10 x 13 mL, 400-600 tests Product No. K801821 |
| Glass Slides | FLEX IHC Microscope Slides (Code K8020) Recommended for greater adherence | 5 x 100 slides Product No. K802021-2 |
Synonym(s) for Antigen
14-3-2 protein, g-enolase, NSE