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Polyclonal Rabbit Anti-Human
Prostate-Specific Antigen (PSA)
Prostate-specific antigen (PSA) is a 33 kDa protein belonging to the kallikrein family of proteases. It is primarily produced by the prostatic epithelium and the epithelial lining of the periurethal glands.
PSA is strongly expressed in both normal and neoplastic prostatic tissue. The antibody has been shown to label prostate carcinomas.
Prostatic adenocarcinoma stained with FLEX Anti-Prostate-Specific Antigen, Code IR514/IS514.
Prostatic adenocarcinoma. The neoplastic cells show a heterogeneous staining reaction.
Clinical application for IR514/IS514 For identification of tumors of prostatic origin.
Disclaimer: Due to variances among color computer monitors, the colors you see on your screen may not be the exact colors of the stain. The image you see should be considered close renditions to the actual stain.
- Optimized staining performance of both high- and low-expression structures
- Crisp and clear staining with no background
- Optimal laboratory efficiency with ready-to-use antibodies on Dako Autostainer Plus
FLEX Polyclonal Rabbit Anti-Human Prostate Specific Antigen, Ready-to-Use (Dako Autostainer/Autostainer Plus), is intended for use in immunohistochemistry together with Dako Autostainer/Autostainer Plus instruments. This antibody is useful for the identification of human prostate-specific antigen (PSA) in immunohistochemistry (1, 2). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
The specificity of the antibody has been ascertained as follows:
Crossed immunoelectrophoresis: Only the PSA precipitation arch appears when using 12.5 µL concentrated antibody per cm2 gel area against 2 µL human seminal fluid. When using 12.5 µL antibody per cm2 gel area against 2 µL human plasma no precipitate is seen. Staining: Coomassie Brilliant Blue.
- Gillespie JW, Best CJM, Bichsel VE, Cole KA, Greenhut SF, Hewitt SM, et al. Technical advance. Evaluation of non-formalin tissue fixation for molecular profiling studies. Am J Pathol 2002;160:449-57.
- Meng FJ, Shan A, Jin L, Young CYF. Short communication: The expression of a variant prostate-specific antigen in human prostate. Cancer Epidemiol Biomarkers Prev 2002;11:305-9
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| Product | Size |  | IS514
| 30 tests, 6 mL Product No. IS51430-2 |
|---|
RECOMMENDED COMPANION PRODUCTS
| Step | Product | Size |
|---|---|---|
| Pre-treatment | EnVision™ FLEX Target Retrieval Solution, High pH (Code K8004) 3-in-1 procedure using PT Link | 3 x 30 mL Product No. K800421 |
| Antibody Dilution | Ready-to-use / Prediluted | |
| Negative Control | FLEX Negative Control, Rabbit (Code IS600) Positive tissue: Prostate | 60 tests, 12 mL Product No. IS60061-2 |
| Visualization System | EnVision™ FLEX (Code K8010) Use High pH Target Retrieval Solution | 400-600 tests Product No. K801021 |
| Counterstain | Hematoxylin (Dako Autostainer/Autostainer Plus) (Code K8018) Non-aqueous, permanent mounting medium is required | 10 x 13 mL, 400-600 tests Product No. K801821 |
| Glass Slides | FLEX IHC Microscope Slides (Code K8020) Recommended for greater adherence | 5 x 100 slides Product No. K802021-2 |
Synonym(s) for Antigen
kallikrein 3, PSA