LAST PRODUCTS VIEWED
RELATED PRODUCT TAGS
Monoclonal Mouse Anti-Human
CD57
Clone TB01
CD57 is expressed by subsets of NK cells and CD8+ lymphocytes, and by a small percentage of CD4+/CD45R0+ T lymphocytes in lymph node germinal centres.
The number of CD57+ cells increases in some pathologies characterized by an imbalance of CD4/CD8 lymphocytes. Normal neuroectodermal cells and striated muscle as well as their neoplastic counterparts also express CD57. Antibodies to CD57 may be useful for the identification of T-cell large granular lymphocyte disorders, oligodendrogliomas and neuroendocrine tumors, and assist in the identification of lymphocytic and histiocytic (L&H) cells of lymphocyte predominant Hodgkin's disease.
- Leong AS-Y, Cooper K, Leong FJW-M. CD 57. Manual of diagnostic antibodies for immunohistology. London: Oxford University Press; 1999. p. 103-6.
- Funaro A, Malavasi F. NK5. CD57 Workshop panel report. In: Kishimoto T, Kikutani H, von dem Borne AEG, Goyert SM, Mason DY, Miyasaka M, et al., editors. Leucocyte typing VI. White cell differentiation antigens. Proceedings of the 6th International Workshop and Conference; 1996 Nov 10-14; Kobe, Japan. New York, London: Garland Publishing Inc.; 1997. p. 274-6.
Hodgkin's lymphoma, lymphocyte predominant subtype, (FFPE) stained with FLEX Anti-CD57, Code IR647/IS647.
Hodgkin lymphoma (LP subtype). T cells surrounding the L&H cells show a distinct membranous staining reaction.
Clinical application for IR647/IS647. For identification of Hodgkin lymphoma (lymphocyte-predominant subtype), T-cell large granular lymphocyte disorder, oligodendroglioma and neuroendocrine tumor.
Disclaimer: Due to variances among color computer monitors, the colors you see on your screen may not be the exact colors of the stain. The image you see should be considered close renditions to the actual stain.
- Optimized staining performance of both high- and low-expression structures
- Crisp and clear staining with no background
- Optimal laboratory efficiency with ready-to-use antibodies on Dako Autostainer Plus
FLEX Monoclonal Mouse Anti-Human CD57, Clone TB01, Ready-to-Use (Dako Autostainer/Autostainer Plus), is intended for use in immunohistochemistry together with Dako Autostainer/Autostainer Plus instruments. Antibodies to CD57 may be useful for the identification of T-cell large granular lymphocyte disorders, oligodendrogliomas and neuroendocrine tumors, and assist in the identification of lymphocytic and histiocytic (L&H) cells of lymphocyte-predominant Hodgkin's disease (1). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
Clone: TB01 (2-4). Isotype: IgM, kappa.
- Leong AS-Y, Cooper K, Leong FJW-M. CD 57. Manual of diagnostic antibodies for immunohistology. London: Oxford University Press; 1999. p. 103-6.
- Funaro A, Cafforio P, Horenstein A, Magrini E, Ardeleanu C, Guena M, et al. NK3.6. Epitope analysis of human CD57 by means of a panel of newly generated high-affinity murine mAb. In: Schlossman SF, Boumsell L, Gilks W, Harlan JM, Kishimoto T, Morimoto C, et al., editors. Leucocyte typing V. White cell differentiation antigens. Proceedings of the 5th International Workshop and Conference; 1993 Nov 3-7; Boston, USA. Oxford, New York, Tokyo: Oxford University Press; 1995. Volume 2. p. 1412-4.
- Funaro A, Cafforio P, Horenstein A, Magrini E, Ardeleanu C, Geuna M, et al. NK5. Human CD57, a link molecule between leucocytes and neural cells. In: Schlossman SF, Boumsell L, Gilks W, Harlan JM, Kishimoto T, Morimoto C, et al., editors. Leucocyte typing V. White cell differentiation antigens. Proceedings of the 5th International Workshop and Conference; 1993 Nov 3-7; Boston, USA. Oxford, New York, Tokyo: Oxford University Press; 1995. Volume 2. p. 1435-6.
- Funaro A, Malavasi F. NK5. CD57 Workshop panel report. In: Kishimoto T, Kikutani H, von dem Borne AEG, Goyert SM, Mason DY, Miyasaka M, et al., editors. Leucocyte typing VI. White cell differentiation antigens. Proceedings of the 6th International Workshop and Conference; 1996 Nov 10-14; Kobe, Japan. New York, London: Garland Publishing Inc.; 1997. p. 274-6.
- Eriksson M, Meadows SK, Wira CR, Sentman CL. Unique phenotype of human uterine NK cells and their regulation by endogenous TGF-ß. J Leukoc Biol 2004;76:667-75.
Check Your Price & Order Online
| Product | Size |  | IS647 Clone TB01
| 30 tests, 6 mL Product No. IS64730-2 |
|---|