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Polyclonal Rabbit Anti-Human
Calcitonin
Calcitonin is a 32 amino acid peptide hormone, produced in the parafollicular C cells of the thyroid.
Calcitonin acts through its receptors, causing osteoclast-mediated bone resorption and calcium excretion by the kidney. The antibody is useful for the identification of calcitonin-producing C cells, from which medullary thyroid carcinoma originates.
- Formalin
- HIER
Thyroid medullary carcinoma (FFPE) stained with FLEX Anti-Calcitonin, Code IR515/IS515.
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Thyroid medullary carcinoma. The neoplastic cells show a strong staining reaction for calcitonin.
Clinical application for IR515/IS515. For identification of thyroid medullary carcinoma and thyroid C cells.
Thyroid medullary carcinoma. The neoplastic cells show a strong cytoplasmic staining reaction.
Clinical application for IR515/IS515. For identification of thyroid medullary carcinoma and thyroid C cells.
Thyroid. A thyroid C cell showing a strong cytoplasmic staining reaction.
Recommended control for IR515/IS515. Thyroid.
Thyroid medullary carcinoma stained with Anti-Calcitonin.
Clinical application for IR515/IS515. For identification of thyroid medullary carcinoma and thyroid C cells.
Disclaimer: Due to variances among color computer monitors, the colors you see on your screen may not be the exact colors of the stain. The image you see should be considered close renditions to the actual stain.
- Concentrated Antibody
for Manual Use - Ready-to-use Antibody
for Autostainer Link Instrument - Ready-to-use Antibody
for Autostainer Plus Instrument
- Excellent specificity
- High lot to lot consistency
- Optimized for immunohistochemistry (IHC) with validated protocols
- Certified manufacturing facilities guarantee full quality control
Intended Use
For in vitro diagnostic use.
Polyclonal Rabbit Anti-Human Calcitonin, Code A0576, is intended for use in immunohistochemistry. The antibody labels calcitonin-producing C-cells, from which medullary thyroid carcinoma (MTC) originates (1). Differential identification is aided by the results from a panel of antibodies. Interpretation of results must be made within the context of the patient's clinical history and other diagnostic tests by a certified professional.
Polyclonal Rabbit Anti-Human Calcitonin, Code A0576, is intended for use in immunohistochemistry. The antibody labels calcitonin-producing C-cells, from which medullary thyroid carcinoma (MTC) originates (1). Differential identification is aided by the results from a panel of antibodies. Interpretation of results must be made within the context of the patient's clinical history and other diagnostic tests by a certified professional.
Immunogen
Synthetic human calcitonin, aa 1-32, coupled to bovine serum albumin (BSA).
Specificity
The antibody reacts with human calcitonin. Traces of contaminating antibodies have been removed by solid-phase absorption with human plasma and bovine serum proteins.
The antibody labels human thyroid C-cells, and other calcitonin-containing cells strongly and specifically. No non-specific staining has been observed.
As demonstrated by immunocytochemistry, the antibody cross-reacts with the calcitonin-equivalent protein in horse and swine.
The antibody labels human thyroid C-cells, and other calcitonin-containing cells strongly and specifically. No non-specific staining has been observed.
As demonstrated by immunocytochemistry, the antibody cross-reacts with the calcitonin-equivalent protein in horse and swine.
Reagent Provided
Purified immunoglobulin fraction of rabbit antiserum provided in liquid form. In 0.1 mol/L NaCl, 15 mmol/L NaN3.
Protein concentration g/L: See label on vial.
The titre variation between different lots of A0576 is less than 10%. This is achieved by adjusting the titre of each individual lot to match the titre of an antibody reference preparation kept at -80 °C.
Protein concentration g/L: See label on vial.
The titre variation between different lots of A0576 is less than 10%. This is achieved by adjusting the titre of each individual lot to match the titre of an antibody reference preparation kept at -80 °C.
References
- Hayashida CY, Alves VAF, Kanamura CT, Ezabella CL, Abelin NM, Nicolau W, et al. Immunohisto-chemistry of medullary thyroid carcinoma and C-cell hyperplasia by an affinity-purified anti-human calcitonin antiserum. Cancer 1993;72:1356-63.
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| Product | Size |  | A0576 Ig fraction
| 1 mL Product No. A057601-2 |
|---|
- Optimized staining performance of both high- and low-expression structures
- Crisp and clear staining with no background
- Optimal laboratory efficiency with ready-to-use antibodies on Dako Autostainer Link 48
Intended Use
For in vitro diagnostic use.
FLEX Polyclonal Rabbit Anti-Human Calcitonin, Ready-to-Use (Link), is intended for use in immunohistochemistry together with Autostainer Link instruments. This antibody is useful for the identification of calcitonin-producing C-cells, from which medullary thyroid carcinoma (MTC) originates (1). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
FLEX Polyclonal Rabbit Anti-Human Calcitonin, Ready-to-Use (Link), is intended for use in immunohistochemistry together with Autostainer Link instruments. This antibody is useful for the identification of calcitonin-producing C-cells, from which medullary thyroid carcinoma (MTC) originates (1). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
Immunogen
Synthetic human calcitonin, aa 1-32, coupled to bovine serum albumin (BSA).
Specificity
The antibody reacts with human calcitonin. Traces of contaminating antibodies have been removed by solid-phase absorption with human plasma and bovine serum proteins.
The antibody labels human thyroid C-cells, and other calcitonin-containing cells strongly and specifically. No non-specific staining has been observed.
The antibody labels human thyroid C-cells, and other calcitonin-containing cells strongly and specifically. No non-specific staining has been observed.
Reagent Provided
Ready-to-use polyclonal rabbit antibody provided in liquid form in a buffer containing stabilizing protein and 0.015 mol/L NaN3
References
- Hayashida CY, Alves VAF, Kanamura CT, Ezabella CL, Abelin NM, Nicolau W, et al. Immunohisto-chemistry of medullary thyroid carcinoma and C-cell hyperplasia by an affinity-purified anti-human calcitonin antiserum. Cancer 1993;72:1356-63.
Check Your Price & Order Online
| Product | Size | | IR515 RTU, FLEX
| 60 tests, 12 mL Product No. IR51561-2 |
|---|
RECOMMENDED COMPANION PRODUCTS
| Step | Product | Size |
|---|---|---|
| Pre-treatment | EnVision™ FLEX Target Retrieval Solution, High pH (Code K8004) 3-in-1 procedure using PT Link | 3 x 30 mL Product No. K800421-2 |
| Antibody Dilution | Ready-to-use / Prediluted | |
| Negative Control | FLEX Negative Control, Rabbit (Code IR600) Positive tissue: Thyroid | 120 tests, 24 mL Product No. IR60066-2 |
| Visualization System | EnVision™ FLEX (Code K8000) Use High pH Target Retrieval Solution | 400-600 tests Product No. K800021-2 |
| Counterstain | Hematoxylin (Link) (Code K8008) Non-aqueous, permanent mounting medium is required | 3 x 45 mL, 400-600 tests Product No. K800821-2 |
| Glass Slides | FLEX IHC Microscope Slides (Code K8020) Recommended for greater adherence | 5 x 100 slides Product No. K802021-2 |
- Optimized staining performance of both high- and low-expression structures
- Crisp and clear staining with no background
- Optimal laboratory efficiency with ready-to-use antibodies on Dako Autostainer Plus
Intended Use
For in vitro diagnostic use.
FLEX Polyclonal Rabbit Anti-Human Calcitonin, Ready-to-Use (Dako Autostainer/Autostainer Plus), is intended for use in immunohistochemistry together with Dako Autostainer/Autostainer Plus instruments. This antibody is useful for the identification of calcitonin-producing C-cells, from which medullary thyroid carcinoma (MTC) originates (1). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
FLEX Polyclonal Rabbit Anti-Human Calcitonin, Ready-to-Use (Dako Autostainer/Autostainer Plus), is intended for use in immunohistochemistry together with Dako Autostainer/Autostainer Plus instruments. This antibody is useful for the identification of calcitonin-producing C-cells, from which medullary thyroid carcinoma (MTC) originates (1). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
Immunogen
Synthetic human calcitonin, aa 1-32, coupled to bovine serum albumin (BSA).
Specificity
The antibody reacts with human calcitonin. Traces of contaminating antibodies have been removed by solid-phase absorption with human plasma and bovine serum proteins.
The antibody labels human thyroid C-cells, and other calcitonin-containing cells strongly and specifically. No non-specific staining has been observed.
The antibody labels human thyroid C-cells, and other calcitonin-containing cells strongly and specifically. No non-specific staining has been observed.
Reagent Provided
Ready-to-use polyclonal rabbit antibody provided in liquid form in a buffer containing stabilizing protein and 0.015 mol/L NaN3.
References
- Hayashida CY, Alves VAF, Kanamura CT, Ezabella CL, Abelin NM, Nicolau W, et al. Immunohisto-chemistry of medullary thyroid carcinoma and C-cell hyperplasia by an affinity-purified anti-human calcitonin antiserum. Cancer 1993;72:1356-63.
Check Your Price & Order Online
| Product | Size | | IS515 RTU, FLEX
| 30 tests, 6 mL Product No. IS51530-2 |
|---|
RECOMMENDED COMPANION PRODUCTS
| Step | Product | Size |
|---|---|---|
| Pre-treatment | EnVision™ FLEX Target Retrieval Solution, High pH (Code K8004) 3-in-1 procedure using PT Link | 3 x 30 mL Product No. K800421-2 |
| Antibody Dilution | Ready-to-use / Prediluted | |
| Negative Control | FLEX Negative Control, Rabbit (Code IS600) Positive tissue: Thyroid | 60 tests, 12 mL Product No. IS60061-2 |
| Visualization System | EnVision™ FLEX (Code K8010) Use High pH Target Retrieval Solution | 400-600 tests Product No. K801021-2 |
| Counterstain | Hematoxylin (Dako Autostainer/Autostainer Plus) (Code K8018) Non-aqueous, permanent mounting medium is required | 10 x 13 mL, 400-600 tests Product No. K801821-2 |
| Glass Slides | FLEX IHC Microscope Slides (Code K8020) Recommended for greater adherence | 5 x 100 slides Product No. K802021-2 |