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Monoclonal Mouse Anti-Human

CD20cy

Clone L26

CD20 is a transmembrane, non-glycosylated protein expressed on B-cell precursors and mature B cells, but is lost following differentiation into plasma cells. In resting B cells, CD20 appears in a 33 kDa non-phosphorylated form. After mitogen stimulation, CD20 becomes heavily phosphorylated (35-37 kDa isoforms), and it is a dominant phosphoprotein in activated B cells. The antibody reacts with an intracytoplasmic epitope localized on the CD20 antigen and labels cells of the B-cell lineage. It is a useful tool for the classification of neoplasms of B-cell derivation.

Isotype IgG2a, kappa

  • Frozen
  • Formalin
  • HIER

B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma (FFPE) stained with FLEX Anti-CD20cy, Code IR604/IS604.

Dako Omnis

Autostainer Link

B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma. The majority of the neoplastic cells show a distinct membranous staining reaction.

Clinical application for GA604. For classification of neoplasms of the B-cell lineage.

B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma. The majority of the neoplastic cells show a distinct membranous staining reaction.

Clinical application for GA604. For classification of neoplasms of the B-cell lineage.

Tonsil. The mantle zone and germinal center B cells show a moderate to strong membraneous staining reaction.

Recommended control for GA604. Tonsil.

B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma. The majority of the neoplastic cells show a distinct membranous staining reaction.

Clinical application for IR604/IS604. For classification of neoplasms of the B-cell lineage.

Mantle cell lymphoma. The majority of the neoplastic cells show a distinct membranous staining reaction.

Clinical application for IR604/IS604. For classification of neoplasms of the B-cell lineage.

Tonsil. The mantle zone and germinal center B cells show a moderate to strong, crisp and continuous membrane staining reaction. The squamous epithelial cells should be negative.

Recommended control for IR604/IS604. Tonsil.

Disclaimer: Due to variances among color computer monitors, the colors you see on your screen may not be the exact colors of the stain. The image you see should be considered close renditions to the actual stain.

  • Excellent specificity
  • High lot to lot consistency
  • Optimized for immunohistochemistry (IHC) with validated protocols
  • Certified manufacturing facilities guarantee full quality control
Dako's products are the result of almost 50 years experience ensuring quality and innovation in antibodies and reagents: the genesis of the pathology lab of tomorrow.

ProductSize
For In Vitro Diagnostic UseM0755 Culture supernatant
Safety Data Sheet:
Non-hazard classification statement
0.2 mL
Product No. M075529-2
1 mL
Product No. M075501-2

  • Optimized staining performance of both high and low-expression structures
  • Dako Omnis and the dynamic gap staining technology provides a consistent, uniform staining with excellent morphology
  • Crisp and clear staining with no background
  • Optimal laboratory efficiency with ready-to-use antibodies on Dako Omnis
The staining performance of all antibodies has been defined, tested and approved through collaboration with leading, international pathologists.

ProductSize
For In Vitro Diagnostic UseGA604 RTU, FLEX
Safety Data Sheet:
Non-hazard classification statement
60 tests, 12 mL
Product No. GA60461

RECOMMENDED COMPANION PRODUCTS

StepProductSize
Pre-treatmentEnVision™ FLEX Target Retrieval Solution, High pH (Code K8004)
3-in-1 procedure using PT Link
3 x 30 mL
Product No. K800421-2
Antibody Dilution
Ready-to-use / Prediluted
 
Negative ControlFLEX Negative Control, Mouse (Code IR750)
Positive tissue: Tonsil and liver
120 tests, 24 mL
Product No. IR75066-2
Visualization SystemEnVision™ FLEX (Code K8000)
Use High pH Target Retrieval Solution
400-600 tests
Product No. K800021-2
CounterstainHematoxylin (Link) (Code K8008)
Non-aqueous, permanent mounting medium is required
3 x 45 mL, 400-600 tests
Product No. K800821-2
Glass SlidesFLEX IHC Microscope Slides (Code K8020)
Recommended for greater adherence
5 x 100 slides
Product No. K802021-2

  • Optimized staining performance of both high and low-expression structures
  • Crisp and clear staining with no background
  • Optimal laboratory efficiency with ready-to-use antibodies on Autostainer Link 48
The staining performance of all antibodies has been defined, tested and approved through collaboration with leading international pathologists. Check the Atlas of Stains - a guide to diagnostic accuracy.

ProductSize
For In Vitro Diagnostic UseIR604 RTU, FLEX
Safety Data Sheet:
Non-hazard classification statement
60 tests, 12 mL
Product No. IR60461-2

RECOMMENDED COMPANION PRODUCTS

StepProductSize
Pre-treatmentEnVision™ FLEX Target Retrieval Solution, High pH (Code K8004)
3-in-1 procedure using PT Link
3 x 30 mL
Product No. K800421-2
Antibody Dilution
Ready-to-use / Prediluted
 
Negative ControlFLEX Negative Control, Mouse (Code IS750)
Positive tissue: Tonsil and liver
60 tests, 12 mL
Product No. IS75061-2
Visualization SystemEnVision™ FLEX (Code K8010)
Use High pH Target Retrieval Solution
400-600 tests
Product No. K801021
CounterstainHematoxylin (Dako Autostainer/Autostainer Plus) (Code K8018)
Non-aqueous, permanent mounting medium is required
10 x 13 mL, 400-600 tests
Product No. K801821-2
Glass SlidesFLEX IHC Microscope Slides (Code K8020)
Recommended for greater adherence
5 x 100 slides
Product No. K802021-2

  • Optimized staining performance of both high and low-expression structures
  • Crisp and clear staining with no background
  • Optimal laboratory efficiency with ready-to-use antibodies on Dako Autostainer Plus
The staining performance of all antibodies has been defined, tested and approved through collaboration with leading international pathologists. Check the Atlas of Stains - a guide to diagnostic accuracy.

ProductSize
For In Vitro Diagnostic UseIS604 RTU, FLEX
Safety Data Sheet:
Non-hazard classification statement
30 tests, 6 mL
Product No. IS60430-2

Synonym(s)

L26

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